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Oncolytic adenoviral vector expressing GM-CSF exhibits anti-tumor activity.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- An oncolytic adenoviral vector expressing granulocyte-macrophage colony-stimulating factor (GM-CSF) exhibited strong anti-tumor activity.
"Oncolytic adenoviruses are being tested as biological cancer therapeutics. Ar6pAE2fF (E2F vector) contains the E2F-1 promoter to regulate the expression of the El a gene in cells with a disregulated retinoblastoma pathway. Ar6pAE2fmGmF (E2F-CM vector) includes the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) transgene to enhance anti-tumor activity," scientists writing in the journal Molecular Therapy report.
"Both vectors selectively killed human tumor cells in vitro," stated J. Andrew Bristol and colleagues at Genetic Therapy, Inc. in the United States. "The E2F-GM vector expressed biologically active murine GM-CSF in vitro and GM-CSF was detected for several days in serum and tumor extracts following injections of established human xenograft tumors. In vivo, both vectors showed significant dose-dependent anti-tumor responses. The E2F-CM vector elicited greater efficacy compared to the E2F vector, demonstrating that CM-CSF enhanced the anti-tumor activity, even in immunodeficient nude mice."
The researchers reported, "Histological analysis showed that both vectors ...
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Source: HighBeam Research, Oncolytic adenoviral vector expressing GM-CSF exhibits anti-tumor...