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Dendritic cells prevent metastasis of HPV 16-associated tumors.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Bone marrow-derived dendritic cells exhibited anti-metastatic effects in mice carrying human papillomavirus 16-associated tumors.
"Oncogenic, moderately immunogenic MK16/1/ IIIABC (MK16) cells were previously established by cotransfection of HPV 16 E6/E7 and activated H-ras oncogene DNA into C57BL/6 kidney cells. Subcutaneous transplantation of the MK16 cells produced progressively growing neoplasms that metastasized spontaneously to the lungs," scientists in Czech Republic report.
"In this communication, we report that prophylactic administration of bone marrow-derived dendritic cells (BMDC) as well as dendritic cell (DC) lines DC2.4 and JAWS II at the site of subsequent MK16 tumor transplants inhibited tumor growth and reduced the number of lung metastases," stated Luis Mendoza and collaborators at the Academy of Sciences of the Czech Republic and the Institute of Hematology and Blood Transfusion. "Similarly, in therapeutic experiments, administration of BMDC and DC lines at the site of the growing MK16 tumors or at the site of MK16 tumor residua after surgery inhibited tumor growth. Both BMDC-based vaccines and vaccines based on DC lines had also an antimetastatic effect."
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Source: HighBeam Research, Dendritic cells prevent metastasis of HPV 16-associated tumors.