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Immunogenicity of DNA vaccines boosted by modified vaccinia virus Ankara.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Enhanced T-cell immunogenicity of plasmid DNA vaccines was boosted by recombinant modified vaccinia virus Ankara in humans.
According to published research from England and the United States, "In animals, effective immune responses against malignancies and against several infectious pathogens, including malaria, are mediated by T cells. Here we show that a heterologous prime-boost vaccination regime of DNA either intramuscularly or epidermally, followed by intradermal recombinant modified vaccinia virus Ankara (MVA), induces high frequencies of interferon (IFN)-gamma-secreting, antigen-specific T-cell responses in humans to a pre-erythrocytic malaria antigen, thrombospondin-related adhesion protein (TRAP)."
"These responses are 5- to 10-fold higher than the T-cell responses induced by the DNA vaccine or recombinant MVA vaccine alone, and produce partial protection manifest as delayed parasitemia after sporozoite challenge with a different strain of Plasmodium falciparum," reported Samuel J. McConkey and collaborators at the University of Oxford, ...
- Further European MVA patent for Bavarian Nordic.(modified vaccinia virus...
- Newspaper article from: Pharma Marketletter July 16, 2007 700+ words
...has granted a patent to Bavarian Nordic which further strengthens its intellectual property position on Modified vaccinia virus Ankara (MVA) in Europe. The new patent, EP 1 420 822, belongs to the same family as the issued US patent number...
- Canada's DND requests proposal for MVA pox vaccs.(Department of National...
- Newspaper article from: Pharma Marketletter April 16, 2007 700+ words
...The Department of National Defence in Canada has requested a purchase proposal for the acquisition of modified vaccinia virus Ankara-based smallpox vaccine for 10,000 people and an option for another 10,000 units. A prerequisite for the...
- Oxxon Pharmaccines Ltd. of Oxford, UK, strengthened its hold on the use of...
- Newspaper article from: BioWorld International April 17, 2002 700+ words
* Oxxon Pharmaccines Ltd., of Oxford, UK, strengthened its hold on the use of Modified Vaccinia virus Ankara (MKA) in therapeutic vaccines, agreeing to a license with Alphapharma Inc. covering the worldwide use of recombinant virus...
- Method developed to monitor immune response against vaccinia virus.
- News wire article from: Bioterrorism Week May 31, 2004 700+ words
...neutralization assay based on a modified vaccinia virus Ankara (MVA) vector expressing the...Neutralization assay using a modified vaccinia virus Ankara vector expressing the green...humoral immune response against vaccinia virus. Clin Diagn Lab Immunol...
- Modified vaccinia virus elicits antibodies to cytomegalovirus strains.
- Newspaper article from: Vaccine Weekly June 16, 2004 700+ words
...Recombinant modified vaccinia virus Ankara expressing a soluble form...attenuated poxvirus, modified vaccinia virus Ankara (MVA), has been constructed...Virology (Recombinant modified vaccinia virus Ankara expressing a soluble form...
- Vaccinia virus expressing RSV genes does not predispose for immunopathology.
- Newspaper article from: Biotech Week April 28, 2004 700+ words
...with a recombinant modified vaccinia virus Ankara expressing the respiratory...of a recombinant modified vaccinia virus Ankara (MVA) vector expressing...with a recombinant modified vaccinia virus Ankara expressing the respiratory...
- Accidental infection of laboratory worker with vaccinia virus. (Dispatches).
- Magazine article from: Emerging Infectious Diseases Moussatche, Nissin Tuyama, Mari Kato, Sayuri E.M. Castro, Ana Paula V. Njaine, Brian Peralta, Regina H. Peralta, Jose M. Damaso, Clarissa R.A. Barroso, Paulo F. June 1, 2003 700+ words
...inoculation of a laboratory worker with vaccinia virus. Although the patient had previously...virus recovered from the lesions. The vaccinia virus--specific immunoglobulin G levels...smallpox vaccine, formulated with vaccinia virus, is a highly effective immunizing...
- Lack of transmission of vaccinia virus.(Letter to the editor)
- Magazine article from: Emerging Infectious Diseases Stark, James H. Frey, Sharon E. Blum, Paul S. Monath, Thomas P. April 1, 2006 700+ words
...spread of the live attenuated vaccinia virus is considered the predominant...have measured the presence of vaccinia virus on the dressings or hands...however, the recovery of vaccinia virus in the environment has not...
- Vaccinia virus encodes previously uncharacterized inhibitor of apoptosis.
- Newspaper article from: Proteomics Weekly January 26, 2004 700+ words
...com & NewsRx.net) -- The vaccinia virus encodes a previously uncharacterized...that function at the mitochondria. Vaccinia virus, the prototypic member of the Poxviridae...previously unidentified protein in vaccinia virus, is responsible for the inhibition...
- Antitumor activity and immune responses induced by a recombinant...
- Newspaper article from: Cancer Weekly July 27, 1992 700+ words
...carcinoembryonic antigen (CEA) with a specific vaccinia virus has been shown to have antitumor activity...National Cancer Institute researchers. Vaccinia virus, used for the eradication of smallpox...the poxvirus family. A recombinant vaccinia virus expressing human immunodeficiency ...
Source: HighBeam Research, Immunogenicity of DNA vaccines boosted by modified vaccinia virus...