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Dendritic cell vaccines offer new hope for treatment of endocrine tumors.

Vaccine Weekly

| August 13, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Dendritic cell vaccines offer new hope for the treatment of metastasized endocrine malignancies.

"Dendritic cells (DCs) are antigen-presenting cells that are involved in the induction of primary immune responses. The unique ability of DCs to activate naive and memory CD4+ and CD8+ T cells suggests that they could be used for the induction of a specific antitumor immunity. In the past few years, several in vitro and in vivo studies in rodents and humans have demonstrated that immunizations with DCs pulsed with tumor antigens result in protective immunity and rejection of established tumors in various malignancies," scientists writing in the journal Trends in Endocrinology and Metabolism report.

"Here, we focus on recent results of how DCs regulate immune responses that are important for generating antitumor cytotoxic T cells, and summarize clinical vaccination trials for the treatment of endocrine and nonendocrine carcinomas," stated Matthias Schott and Jochen Seissler at Heinrich-Heine-University Dusseldorf in Germany. "Preliminary results ...

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Source: HighBeam Research, Dendritic cell vaccines offer new hope for treatment of endocrine...

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