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Pneumococcal vaccination decreases atherosclerotic lesion formation.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- Pneumococcal vaccination decreased atherosclerotic lesion formation, indicating molecular mimicry between Streptococcus pneumoniae and oxidized LDL.
According to a study from the United States, "During the progression of atherosclerosis, autoantibodies are induced to epitopes of oxidized low-density lipoprotein (oxLDL) and active immunization of hypercholesterolemic mice with oxLDL ameliorates atherogenesis. We unexpectedly found that many autoantibodies to oxLDL derived from 'naive' atherosclerotic mice share complete genetic and structural identity with antibodies from the classic anti-phosphorylcholine B-cell clone, T15, which protect against common infectious pathogens, including pneumococci."
"To investigate whether in vivo exposure to pneumococci can affect atherogenesis, we immunized Ldlr-/- mice with Streptococcus pneumoniae," stated Chritoph J. Binder and colleagues at the University of California-San Diego. "This induced high circulating levels of oxLDL-specific IgM and a persistent expansion of oxLDL-specific T15 IgM-secreting B cells primarily in the spleen, which were cross-reactive with pneumococcal determinants. Pneumococcal immunization decreased ...
- Pneumococcal vaccination decreases atherosclerotic lesion formation.
- Newspaper article from: Drug Week August 15, 2003 700+ words
...NewsRx.net) -- Pneumococcal vaccination decreased atherosclerotic...of their research in Nature Medicine (Pneumococcal vaccination decreases atherosclerotic...publisher of the journal Nature Medicine can be contacted at...
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...studies, we hypothesized that pneumococcal vaccination would protect patients from myocardial...0.46). Interpretation: Pneumococcal vaccination was associated with a decrease...offer another reason to promote pneumococcal vaccination. Une version franaise de ce rsum...
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- Newspaper article from: Morbidity and Mortality Weekly Report January 31, 2003 700+ words
...have shown improved influenza and pneumococcal vaccination rates through standing orders...improve access to influenza and pneumococcal vaccination in hospitals, LTCFs, and HKAs...VP, Strikas RA. Influenza and pneumococcal vaccination in nursing homes, U.S., 1995...
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...and the objective of 60% for pneumococcal vaccination was nearly met in 2000, vaccine...ethnic disparities in influenza and pneumococcal vaccination coverage have persisted over time...unknown status for influenza or pneumococcal vaccination were excluded from the analyses...