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Focal and generalized folliculitis common after smallpox vaccination.
2003 AUG 13 - (NewsRx.com & NewsRx.net) -- by Maria G. Essig, MS, ELS, senior medical writer - Focal and generalized folliculitis was noted in people immunized against smallpox for the first time, according to a report in the Journal of the American Medical Association.
"With the reintroduction of smallpox vaccination, detailed contemporary descriptions of adverse reactions to the vaccine are needed to adequately inform the public and clinicians," said Thomas R. Talbot and colleagues at Vanderbilt University in the United States. "During a multicenter, randomized controlled trial investigating the efficacy of various dilutions of smallpox vaccine, we observed the appearance of a papulovesicular eruption (focal and generalized) in study volunteers."
The researchers monitored the occurrence of papulovesicular eruptions in 148 vaccinia-naive adults (63 men, 83 women), average age 23.6 years, who received smallpox vaccinations from October 2002 to March 2003.
Generalized eruptions occurred in 4 subjects (2.7%) and focal eruptions developed in 11 individuals (7.4%). Evidence of suppurative folliculitis without viral infection was indicated in the biopsy specimen from one patient who developed a generalized rash (Focal and generalized folliculitis following smallpox vaccination among vaccinia-naive recipients. JAMA - Journal of the American Medical Association, 2003;289(24):3290-3294).
"Viral cultures of sample lesions were negative for vaccinia," reported Talbot and his collaborators. "All lesions resolved ...
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