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Mutation CDP may allow tumor growth.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Mutation CDP may allow tumor growth.
According to published research from Australia, "Leiomyomas are the most common gynecologic tumors in women, but very little is known about their molecular pathology.
"We used single-stranded conformational polymorphism/heteroduplex analysis to analyze 42 unselected uterine leiomyomas for somatic mutations in all coding exons of the gene encoding CCAAT displacement protein (CDP), as well as exons 5-8 of TP53 and codons 1-36 and 38-80 of KRAS," wrote M.I. Patrikis and colleagues, Peter MacCallum Cancer Institute.
"No somatic mutations were identified in either TP53 or KRAS, indicating that disregulation of these genes is not required for leiomyomas development. Aberrant band shifts were identified in CDP, but these were all germline nonpathogenic variants that have been reported previously," the researchers wrote.
"There is good functional and genetic evidence indicating that CDP is a leiomyoma suppressor, but our data suggested that somatic mutations in this ...
- Progen's Anti-cancer Drug Trial Receives Second Site Approval From Peter...
- Press release article from: Business Wire August 26, 1999 700+ words
...Progen Industries Limited (ASX:PGL)(NASDAQ:PGLAF), today received provisional approval from the Peter MacCallum Cancer Institute's Ethics Committee to commence testing its anti-cancer drug, PI-88, at the Institute under the umbrella...
- Peter MacCallum Cancer Centre and Affymetrix Initiate Five-Year Translational...
- Press release article from: Business Wire September 27, 2006 700+ words
...year collaboration with the Peter MacCallum Cancer Centre (Peter Mac) in Melbourne...director of research at the Peter MacCallum Cancer Centre. "We are keen to help our...research organization such as the Peter MacCallum Cancer Centre to help bring more effective...
- Peter MacCallum Cancer Centre Expands Cancer Research Efforts with Automation...
- News wire article from: PR Newswire May 19, 2009 700+ words
...announced a collaboration with the Peter MacCallum Cancer Centre (PMCC), based in Melbourne...and reproducible way. "The Peter MacCallum Cancer Centre's decision to rely on the...Life Sciences, Inc. About Peter MacCallum Cancer Centre In the midst of a worldwide...
- Researchers from Peter MacCallum Cancer Center report on findings in cancer...
- Newspaper article from: Cancer Gene Therapy Week October 5, 2009 700+ words
...receptor," wrote L.J. Berry and colleagues, Peter MacCallum Cancer Center. The researchers concluded: "This review discusses...contact L.J. Berry, Cancer Immunology Program, Peter MacCallum Cancer Centre, Victoria, Australia. Publisher contact information...
- Studies from Peter MacCallum Cancer Center yield new information about myeloma...
- Newspaper article from: Blood Weekly March 12, 2009 700+ words
...0.001)," wrote H. Quach and colleagues, Peter MacCallum Cancer Center (see also Myeloma Therapy). The researchers concluded...For additional information, contact H. Quach, Peter MacCallum Cancer Centre, Division of Haematology and Medical Oncology...
- Research from Peter MacCallum Cancer Center has provided new information about...
- Newspaper article from: Blood Weekly May 14, 2009 700+ words
...treatment site," wrote M. Rodrigues and colleagues, Peter MacCallum Cancer Center. The researchers concluded: "While photodynamic...information, contact M. Rodrigues, Dermatology Service, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. The publisher...
- Investigators at Peter MacCallum Cancer Center zero in on myeloma therapy.
- Newspaper article from: Blood Weekly March 19, 2009 700+ words
...relapse," wrote S.J. Harrison and colleagues, Peter MacCallum Cancer Center. The researchers concluded: "These studies suggest...contacting S.J. Harrison, Haematology Service, Peter MacCallum Cancer Centre, Melbourne, Australia. The publisher of the journal...
- Researchers from Peter MacCallum Cancer Center report recent findings in...
- Newspaper article from: Blood Weekly October 8, 2009 700+ words
...patients," wrote M. Dickinson and colleagues, Peter MacCallum Cancer Center (see also Lymphoma). The researchers concluded...information, contact M. Dickinson, Haematology Service, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. Publisher contact...
Source: HighBeam Research, Mutation CDP may allow tumor growth.