AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Comparative genomic hybridization detected genomic alterations in all 18 cases.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- According to a study from England, "Ovarian clear cell carcinoma (OCCC) accounts for a small but significant proportion of all ovarian cancers and is a distinct clinical and pathological entity.
"It tends to be associated with poorer response rates to chemotherapy and with a worse prognosis. Little is known about possible underlying genetic changes. DNA extracted from paraffin-embedded samples of 18 pure OCCC cases was analyzed for genetic imbalances using comparative genomic hybridization (CGH)," wrote J. Dent and colleagues, St. James University Hospital, Clinical Cancer Center.
"All of the 18 cases showed genomic alterations. The mean number of alterations detected by CGH was six (range 1-15) indicating a moderate level of genetic instability. Chromosome deletions were more common than amplifications. The most prominent change involved chromosome 9 deletions in 10 cases (55%)," the researchers stated.
"This correlates with changes seen in other epithelial ovarian cancers. This deletion was confirmed using microsatellite markers to assess loss of heterozygosity (LOH) at four separate loci on chromosome 9. The most distinct ...
- Comparative genomic hybridization enters the mainstream.(EDITOR'S Note)(Letter...
- Magazine article from: Bioscience Technology Ernst, Steve June 1, 2005 700+ words
...use in a technique known as comparative genomic hybridization (CGH). The...areas of genomic research. "Comparative genomic hybridization for molecular...dnaarrays.org/), and The Cancer Center at the Baylor College of Medicine...
- CGH Arrays Put Out an APB on DNA Variation.(comparative genomic hybridization)
- Magazine article from: Genomics and Proteomics Schu, Bill November 1, 2004 700+ words
...biologists alike now rely on comparative genomic hybridization to study hiccups...specialized tools such as comparative genomic hybridization (CGH) array...Francisco (UCSF) Comprehensive Cancer Center. "Fluorescence ratios on...
- The Report 'Comparative Genomic Hybridization: Current State and Future...
- Press release article from: Business Wire November 6, 2006 700+ words
...has announced the addition of Comparative Genomic Hybridization: Current State and...offering. If you've not yet heard of Comparative Genomic Hybridization (CGH), you will...detecting and monitoring cancer. Comparative Genomic Hybridization: Current State and...
- Low-level genomic instability is a feature of papillary thyroid carcinoma: an...
- Magazine article from: Archives of Pathology & Laboratory Medicine Finn, Stephen Smyth, Paul O'Regan, Esther Cahill, Suzanne Toner, Mary Timon, Conrad Flavin, Richard O'Leary, John Sheils, Orla January 1, 2007 700+ words
* Context.--Previous chromosomal comparative genomic hybridization (CGH) studies of papillary...progression of PTC is needed. Metaphase Comparative Genomic Hybridization Comparative genomic hybridization (CGH) was first described...
- Comparative genomic hybridization can help classify ambiguous lesions.(Brief...
- Newspaper article from: Cancer Weekly April 8, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Comparative genomic hybridization can help classify ambiguous lesions...Japanese patients to illustrate the use of comparative genomic hybridization (CGH) to classify these lesions...
- Comparative genomic hybridization can help classify ambiguous lesions.
- Newspaper article from: Cancer Gene Therapy Week April 7, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Comparative genomic hybridization can help classify ambiguous lesions...Japanese patients to illustrate the use of comparative genomic hybridization (CGH) to classify these lesions...
- Comparative genomic hybridization yields BRCA1 somatic genetic profile.
- Newspaper article from: Cancer Weekly February 11, 2003 700+ words
...group based on somatic genetic profiles as revealed by comparative genomic hybridization. "This technique was performed on breast...Research (Molecular classification of breast carcinomas by comparative genomic hybridization: A specific somatic genetic profile for...
- Comparative Genomic Hybridization A New Tool for Reproductive Pathology.
- Magazine article from: Archives of Pathology & Laboratory Medicine Barrett, Irene J. Lomax, Brenda L. Loukianova, Tatiana Tang, Steven S. Lestou, Valia S. Kalousek, Dagmar K. January 1, 2001 700+ words
...purpose of this study was to evaluate the advantages of comparative genomic hybridization (CGH) analysis for detection of chromosomal...mosaicism may be detected as a contributory factor.[4] Comparative genomic hybridization is a technique that offers a molecular approach...
Source: HighBeam Research, Comparative genomic hybridization detected genomic alterations in all...