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Combination gene therapy overrides ovarian cancer growth.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Combination gene therapy overrides ovarian cancer growth.
"Increased survivin expression is a negative prognostic marker in many tumors, including ovarian cancer. We show here that ovarian carcinoma cells upregulate survivin transcription in response to increased expression of the proapoptotic protein procaspase 3. We have utilized this observation in a combination gene therapy strategy using adenoviral constructs expressing the dominant-negative mutant survivin T34A (Ad Survivin T34A) and procaspase 3 (Ad Caspase 3) in ovarian carcinoma cell lines," scientists writing in the journal Oncogene report.
"Transfection of ovarian carcinoma cells with Ad Survivin T34A induces apoptosis via a caspase 9-mediated pathway that is not affected by cell cycle block prior to G2/M. Ad Survivin T34A-induced apoptosis can be significantly enhanced by cotransfection with Ad Caspase 3, and the combination of Ad Survivin T34A and Ad Caspase 3 leads to a significant increase in survival in a murine intraperitoneal ovarian carcinoma model with some long-term survivors," according to T.R. Mckay and colleagues, Hammersmith ...
- Combination gene therapy overrides ovarian cancer growth.
- Newspaper article from: Cancer Gene Therapy Week August 4, 2003 700+ words
...Combination gene therapy overrides ovarian...a combination gene therapy strategy using...survivin T34A (Ad Survivin T34A) and procaspase...combination of Ad Survivin T34A and Ad Caspase...a combination gene therapy strategy. Oncogene...
- Scientists at Fujian Medical University, Department of Hematology discuss...
- Newspaper article from: Cancer Vaccine Week December 29, 2008 700+ words
...than DCs infected with Ad-survivin only, Ad-GM-CSF...DCs coinfected with Ad-survivin and Ad-GM-CSF were...DCs coinfected with Ad-survivin and Ad-GM-CSF induce...Hematology (see also Gene Therapy). The researchers...
- Gene therapy: science fiction or reality?
- Magazine article from: Southern Medical Journal Preuss, Meredith A. Curiel, David T. January 1, 2007 700+ words
Gene therapy has been proposed to be the modern medical...mediator of behavior. In the early days of gene therapy, the primary purpose was to develop...associated with disease pathologies, gene therapy strategies have expanded to include...
- Examine Gene Therapy Markets and Technologies Now!
- Press release article from: Business Wire May 12, 2008 700+ words
...has announced the addition of "Gene Therapy - Technologies, Markets and Companies" to their offering. Gene therapy can be broadly defined as the transfer...genetically modified cells, the scope of gene therapy becomes much broader. Gene therapy...
- Gene therapy industry should see brighter days.(Bruce A. Hironaka of Cell...
- Magazine article from: San Diego Business Journal Webb, Marion November 16, 1998 700+ words
Today's gene therapy business looks "bleak," admits...opportunities at last week's third annual Gene Therapy and Genomics meeting at the Westin...There will be a significant demand for gene therapy," Hironaka said in a cheery introductory...
- Gene Therapy Advisory Committee Annual Report published; UK leads Europe in...
- Press release article from: M2 Presswire January 31, 2003 700+ words
...31 January 2003-UK Government: Gene Therapy Advisory Committee Annual Report published...publication of the Eighth Annual Report of the Gene Therapy Advisory Committee (GTAC) for 2001...details of all proposals for clinical gene therapy studies reviewed by GTAC during the...
- Gene therapy benefit said to outweigh risk.
- News wire article from: United Press International October 10, 2002 700+ words
...International via COMTEX) The benefits of gene therapy far outweigh its risks and such procedures...emergency meeting Thursday to examine gene therapy safety issues following the report last...In addition, a clinical trial of gene therapy in France being conducted at the Hopital...
- GENE THERAPY.
- Magazine article from: The Exceptional Parent Meyers, Abbey S. March 1, 2000 700+ words
...1999, four days after receiving a gene therapy infusion at the University of Pennsylvania...first that could be directly linked to gene therapy--electrified the scientific community...have a powerful impact on the future of gene therapy experiments and how they are approved...
