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Aromatase associates with vascular permeability in human breast cancer tissues.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Aromatase associates with vascular permeability in human breast cancer tissues.
"We examined, by immunohistochemical analysis, the expression of aromatase and estrone sulfatase (E1-STS) which are the two major enzymes involved in in situ estrogen synthesis in breast cancer tissue. In the 83 cases examined, E1-STS, which hydrolyzes estrone sulfate (EIS) to estrone (E1), was dominantly detected in tumor cells in 43 (59.0%) cases," scientists writing in the journal Oncology Reports reported.
"Aromatase, which converts androgens to estrogens, was dominantly detected in stromal cells of the tumor. It was detected in 39 (47.0%) of the 83 cases. There was no significant correlation between the expression of these two enzymes and clinicopathological factors," said Y. Yamamoto and colleagues, Kumamoto University, School of Medicine.
"We found a tendency for a correlation between aromatase expression and E1-STS expression in breast tumor (p = 0.075). In terms of the possible use of these enzymes as prognostic indicators, patients who had aromatase in their tumor showed longer relapse-free survival than those lacking aromatase (p = 0.045)."
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