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Late-term exposure to SSRIs may cause neurological symptoms in babies.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Infants whose mothers took selective serotonin reuptake inhibitors (SSRIs; drugs used to treat some psychiatric disorders) during late pregnancy are at an increased risk for having neurologic adverse effects linked to the drugs during the first weeks of life, researchers in Finland report.
Mood and anxiety disorders such as depression, panic disorder, and obsessive-compulsive disorder are common in women during child-bearing years, according to the researchers' paper in the July 2003 issue of the Archives of General Psychiatry. SSRIs, which increase the availability of the neurotransmitter serotonin, are often used in the treatment of mental disorders in pregnant women. Previous studies suggest that taking SSRIs during the third trimester may lead to neurologic symptoms in newborns, including irritability, constant crying, eating and sleeping difficulties, and even convulsions.
Kari Laine, MD, PhD, of the University of Turku, Finland, and colleagues studied the effects of SSRIs on newborns exposed to the drugs during the third trimester of pregnancy. The researchers enrolled 40 pregnant women in their study between January 1, 1997, and August 31, 2000. Twenty of the women were taking SSRIs during pregnancy and breastfeeding. The other 20 women were not taking any psychoactive medications.
The newborns were assessed for serotonin-related neurologic symptoms including muscle spasms, restlessness, tremor, shivering, rigidity, and poor coordination on the first 4 days of life and again at 2 weeks and 2 months after delivery. Infants also underwent brain ultrasound and ...
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Source: HighBeam Research, Late-term exposure to SSRIs may cause neurological symptoms in babies.