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Chemokine receptor CXCR1 is variably expressed following the menstrual cycle.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Human endometrium expresses chemokine receptors CXCR2 and CCR5 consistently, but CXCR1 variably dependent on the menstrual cycle.
According to recent research published in the journal Biology of Reproduction, "Chemokines play a role in endometrial physiology and pathology and may affect endometrial receptivity and menstrual shedding. Chemokines exert their effect by binding to their relevant receptors, the expression levels of which may modulate their action.
"In the present study, we examined the expression of chemokine receptors CXCR1 and CXCR2 (receptors for IL-8) and CCR5 (receptor for RANTES [regulated-on-activation, normal-T-cell-expressed and -secreted], macrophage inflammatory protein [MIP]-1alpha, and MIP-1beta) in human endometrium."
"Human endometria (n=35) were grouped according to the menstrual cycle phase and examined by immunohistochemistry for CXCR1, CXCR2, and CCR5. In both epithelial and stromal cells, CXCR1 and CXCR2 immunoreactivity was detected. Staining was most prominent at the apical and basal aspects of epithelial cells. Intense CCR5 immunostaining was observed in epithelial and stromal compartments throughout the menstrual cycle. Epithelial and stromal staining for CXCR1 ...
- Chemokine receptor up-regulated after skin injury but unneeded for healing.
- Newspaper article from: Biotech Week June 30, 2004 700+ words
...com & NewsRx.net) -- The chemokine receptor CCR1 is strongly up-regulated after...the identified genes encodes the chemokine receptor CCR1, which binds several chemokines...due to redundancy in chemokine/chemokine receptor signaling," concluded the researchers...
- Chemokine receptor 5 dispensable response to Listeria monocytogenes.
- Newspaper article from: AIDS Weekly April 26, 2004 700+ words
...com & NewsRx.net) -- Chemokine receptor 5 is dispensable for innate and adaptive...Listeria monocytogenes infection. "Chemokine receptor 5 (CCR5) binds macrophage inflammatory...study in Infection and Immunity (Chemokine receptor 5 is dispensable for innate and adaptive...
- First Chemokine Receptor Antagonist Available Under Expanded Access.
- Magazine article from: Infectious Disease Alert February 1, 2007 700+ words
First Chemokine Receptor Antagonist Available Under Expanded Access...HIV entry inhibitor that binds to the CCR5 chemokine receptor on the surface of T-cells. This chemokine receptor is normally the receptor for the chemokines...
- Antibody light chain cleaves chemokine receptor CCR-5 peptide.
- Newspaper article from: AIDS Weekly June 7, 2004 700+ words
...light chain capable of cleaving a chemokine receptor CCR-5 peptide with a high reaction...possessing a part of a sequence of a chemokine receptor, CCR-5, which is present as a...light chain capable of cleaving a chemokine receptor CCR-5 peptide with a high reaction...
- Chemokine receptor may not play direct role in placental HIV transmission.
- Newspaper article from: Biotech Week June 16, 2004 700+ words
...JUN 16 - (NewsRx.com & NewsRx.net) -- The chemokine receptor CXCR4 may not play a direct role in HIV transmission in...as angiogenesis and proliferation. Besides, CXCR4, a chemokine receptor, is one of the two major co-receptors for entry of...
- Chemokine receptor-mediated leukocyte vascular recognition analysis useful.
- Newspaper article from: Immunotherapy Weekly April 2, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Chemokine receptor-mediated leukocyte vascular recognition analysis...models of intravital microscopy for analysis of chemokine receptor-mediated leukocyte vascular recognition...
- NOVEL CHEMOKINE RECEPTOR 9 POLYMORPHISMS: CANDIDATE GENES FOR CROHN'S DISEASE...
- Magazine article from: Gut McGovern, D.P.B. Heel, D.A. van Dechairo, B. Ahmad, T. Lench, N.J. Jewell, D.P. March 1, 2001 700+ words
...studies have implicated 3p21 as a susceptibility locus for IBD. The chemokine receptor cluster (3p21.3) is located within this region of linkage. Chemokine receptor 9 (CCR-9) is expressed in high levels on all small bowel CD4+ and...
- Second suspect chemokine receptor identified for cancer.(News From The Lab)
- Newspaper article from: BioWorld Week October 22, 2007 700+ words
...molecular link between inflammation and cancer--the chemokine receptor CXCR7, which is expressed on both tumor cells themselves...Importantly, the tumor cells did not express another chemokine receptor:. CXCR4, which, like CXCR7, binds the chemokine CXCL12...
- HIV-1 Env-chemokine receptor interactions in primary human macrophages: entry...
- Magazine article from: Research Initiative/Treatment Action! Collman, Ronald G. March 22, 2003 700+ words
...cellular receptor complex, which comprises CD4 plus a chemokine receptor. While the CD4 receptor is required for infection by...primary macrophages and primary lymphocytes and use the chemokine receptor CCR5 as a co-receptor. T cell-tropic (T-tropic...
- Pharmacopeia Nominates Novel Chemokine Receptor Antagonist for Development.
- Press release article from: PR Newswire February 11, 2008 700+ words
...PS031291 is a potent and highly selective antagonist at the chemokine receptor CCR1, which has been implicated to play a significant...plans to develop PS031291, a product candidate from its chemokine receptor CCR1 program, Pharmacopeia's plans to develop PS433540...
Source: HighBeam Research, Chemokine receptor CXCR1 is variably expressed following the...