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Gene transfection downregulates VEGF expression in endometrial cancer cells.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Gene transfection downregulates VEGF expression in endometrial cancer cells.
"It has been reported that tumor suppressor gene p53 regulates vascular endothelial growth factor (VEGF) expression, but the relation between them in endometrial carcinoma remains unclear. We investigated VEGF expression in 11 endometrial carcinoma cell lines and the effect of p53 gene transfection on VEGF expression in the p53-mutated endometrial carcinoma cell line, HEC-50B," said T. Fujisawa and colleagues, Kitasato University, Graduate School of Medical Sciences.
"Immunoblotting for detecting VEGF, p53, and beta-actin was performed," scientists stated.
"Wild type p53 gene was transfected using the SuperFect method. The mean VEGF value of 0.8[+ or -]0.3 (n = 6) in p53 wild-type group was significantly lower than the 1.6[+ or -]0.8 (n = 5) that was found in the p53 mutant group (p
"Levels of VEGF in the culture medium were measured by enzyme immunoassay (EIA). VEGF levels in the p53 gene-transfected HEC-50B cells and the ...
- Gene transfection downregulates VEGF expression in endometrial cancer cells.
- Newspaper article from: Cancer Gene Therapy Week August 4, 2003 700+ words
...net) -- Gene transfection downregulates...expression in endometrial cancer cells...after p53 gene transfection. VEGF expression...Effect of p53 gene transfection on vascular...expression in endometrial cancer cells. Exp...
- Endometrial Cancer
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Endometrial Cancer Definition Endometrial cancer develops when the cells that make up the inner lining...become abnormal and grow uncontrollably. Description Endometrial cancer (also called uterine cancer) is the fourth most common...
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What is endometrial cancer? Endometrial cancer is a condition in which cancer cells grow in the lining...is also called uterine cancer. How does it occur? Endometrial cancer is seen most often in older women between the ages of...
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- Clinical Reference Systems July 1, 1999 700+ words
What is endometrial cancer? Endometrial cancer is a condition in which cancer cells grow in the lining...is also called uterine cancer. How does it occur? Endometrial cancer is seen most often in older women between the ages of...
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- Cont. Postmenopausal Hormone Therapy May Protect Against Endometrial Cancer.
- Magazine article from: OB/GYN Clinical Alert October 1, 1999 700+ words
...Hormone Therapy May Protect Against Endometrial Cancer Abstract & Commentary Weiderpass...adding progestins on the risk of endometrial cancer associated with postmenopausal estrogen...was examined in 709 patients with endometrial cancer compared with 3368 control women...
- Continuous Combined Postmenopausal Hormone Therapy May Protect Against...
- Magazine article from: Internal Medicine Alert October 29, 1999 700+ words
...associated with an 80% reduced risk of endometrial cancer. Source: Weiderpass E, et al...adding progestins on the risk of endometrial cancer associated with postmenopausal estrogen...was examined in 709 patients with endometrial cancer compared with 3368 control women...
