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RNA interference presents a novel way to treat cancers with viral etiologies.

Women's Health Weekly

| August 07, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 AUG 7 - (NewsRx.com & NewsRx.net) -- RNA interference presents a novel way to treat cancers with viral etiologies.

"The newly discovered phenomenon of RNA interference (RNAi)offers the dual facility of selective viral gene silencing coupled with ease of tailoring to meet genetic variation within the viral genome. Such promise identifies RNAi as an exciting new approach to treat viral-induced diseases, including viral-induced cancers (e.g. cervical carcinoma, hepatocellular carcinomas and hematopoietic and lymphoid malignancies)," according to a study from England.

"Cervical cancer is the second most common cancer in women worldwide and is caused by human papilloma virus (HPV). Silencing of HPV gene expression by RNAi induces apoptosis of cervical carcinoma cells in culture, and the effect is apparent within 3 days," stated J. Milner and colleagues, University of York, Department of Biology.

"The RNAi process is triggered by double-stranded RNA (dsRNA), and a single dose is sufficient to maintain RNAi for ...

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