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Micronucleus assay may correlate with normal tissue damage from radiotherapy.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Micronucleus assay may correlate with normal tissue damage from radiotherapy.
"In an effort to find a test to predict the response of normal tissue to radiotherapy, the lymphocyte micronucleus assay was used on blood samples from patients with cervical carcinoma," scientists writing in the journal Radiation Research report.
"Peripheral blood samples from 55 patients with advanced-stage (11 B-IV B) cervical carcinoma were obtained before radiotherapy. The patients were treated with external-beam radiotherapy followed by high-dose-rate brachytherapy," wrote M. Widel and colleagues, Silesian Technical University.
"Acute and late normal tissue reactions were scored and correlated with the micronucleus frequency in lymphocytes after irradiation with 4 Gy in vitro. Great interindividual variability was observed in the radiation-induced lymphocyte micronucleus frequency, especially at 4 Gy," the researchers stated.
"The mean number of micronuclei per 100 binucleated cells in cells irradiated with 4 Gy in vitro was significantly higher in samples from patients who suffered from acute and/or late normal tissue reactions than in those from patients with no reactions (51.0 [+ or -] 17.7 and 29.6 [+ or -] 10.1, ...
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Source: HighBeam Research, Micronucleus assay may correlate with normal tissue damage from...