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HPV-16 recurrence is associated with differing T cell response to L1 and E7.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Specific T cell responses to HPV-16 proteins L1 and E7 are associated with different disease states and recurrence.
"Human papillomavirus type 16 (HPV-16) L1 and E7 specific T cell responses were measured in 58 women with abnormal cervical cytology in a prospective study. On recruitment, patients responded most frequently and with the highest numbers of responding cells to the L1 region, aa 311-345, and this response was significantly associated with the presence of cervical disease," researchers in England report.
"Responses to the L1 peptide aa 281-295 were significantly higher in patients with CIN III than in those with HPV/CIN I or CIN II lesions (p=0.027). The E7 region aa 70-98 was most immunogenic in patients with squamous intraepithelial lesions of the cervix (SIL) but the responses detected were not significantly higher than in patients without SIL. Following treatment, the T cell response profiles of patient groups did not change significantly. However, on analysis of the responses of individual patients with and without recurrent disease on followup, significant differences were found," wrote J.C. Luxton and coworkers.
The researchers concluded: "Recurrence of disease was associated with T cell responses to the E7 region aa 70-98 at the first clinic visit ...
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Source: HighBeam Research, HPV-16 recurrence is associated with differing T cell response to L1...