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2003 AUG 7 - (NewsRx.com & NewsRx.net) -- HPV testing is valuable in detecting or excluding cervical cancer.
"In a prospective cohort study, 8466 women attending routine cervical cancer screening were recruited. Colposcopy was performed on women with any degree of atypia on cytology and/or a positive high-risk human papillomavirus (HPV)-DNA test (HC2; Hybrid Capture 2), and for a randomly selected sample of 3.4% women with negative findings on both," scientists in Germany report.
"Quality control included reviews of cytology, histology, colposcopy images and retesting of samples with polymerase chain reaction. Test diagnostic performances were based on 7908 women who had complete baseline and follow-up results," wrote K.U. Petry and colleagues, University Clinic Tuebingen.
"Routine histology identified 86 women with high-grade cervical intraepithelial neoplasia (CIN2+), which was confirmed by review histology in only 46 cases. Sensitivity of routine cytology for the detection of CIN2+ was 43.5%, with a specificity, positive predictive value (PPV), negative predictive value (NPV) of 98.0%, 11.4%, and 99.7%, respectively," the researchers wrote.
"Sensitivity of the HC2 test for the detection of CIN2+ was 97.8%, with a specificity, PPV and NPV, of 95.3%, 10.9%, and 100%, ...
Source: HighBeam Research, HPV testing is valuable in detecting or excluding cervical cancer.