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Haplotype II is over-represented among chromosomes harboring mutations in BRCA1.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Haplotype II is over-represented among chromosomes harboring mutations in BRCA1.
According to a study from Spain, "The BRCA1 gene is included in a 200-400 kb region that is subjected to a recombination suppression mechanism; this region shows nearly complete linkage disequilibrium for a series of common biallelic polymorphisms, all of them with rarer allele frequency close to 0.4.
"These series of SNPs define two major haplotypes designated as class I and class II," wrote A. Osorio and colleagues, Spanish National Cancer Center, Department Human Genetics.
"In the present study, we have determined haplotype classes in the index case of 106 breast/ovarian cancer families previously screened for mutations in the BRCA genes and we have found that haplotype II (the less frequent in the control population) is over-represented among chromosomes harboring mutations in BRCA1," the researchers stated.
The researchers concluded: "In addition, we have defined a subtype of chromosomes ...
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Source: HighBeam Research, Haplotype II is over-represented among chromosomes harboring...