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Women should not ingest excessive food additives with estrogenic activity.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Women should not ingest excessive food additives with estrogenic activity.
According to a study from Japan, "Estrogenic activities of more than 90 chemicals including food additives, foodstuffs of plant origin, and some chemicals, which could be orally ingested, were examined by assaying estrogen receptor (ER)-dependent proliferation of MCF-7 cells.
"Among 66 food additives, 17 compounds stimulated the proliferation, but their concentrations giving maximal cell yield were higher than that of 17beta-estradiol and their estrogenic activities were weak. Flavonoids had relatively strong estrogenic activities," wrote T. Okubo and colleagues, Tokyo Metropolitan Public Health Research Laboratory, Department of Environmental Health.
"In the assay of ER competitive binding to human ERalpha and ERbeta in vitro, the antioxidant t-butylhydroxyanisole (BHA) had the capacity to compete with 17beta-estradiol, while the capacity of o-phenyl phenol (OPP) was too small to calculate," the researchers wrote.
"Both BHA and OPP induced a decrease in gene expression of ERa and an increase in that of progesterone receptor in a ...
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Source: HighBeam Research, Women should not ingest excessive food additives with estrogenic...