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There may be a functional relationship between breast adenocarcinoma and COX-2.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, senior medical writer - Scientists believe there may be a functional relationship between the enzyme cyclooxygenase-2 (COX-2) and the angiogenesis, or new vessel growth, of human breast cancer.
If such a relationship indeed exists, then COX-2 inhibitors might be viable for treating such cancers, the scientists say.
"COX-2 is overexpressed in breast cancer and may have a role in regulating tumor growth via effects on angiogenesis, cell proliferation, and apoptosis," said Giles Davies and colleagues, who are researchers at Royal Marsden Hospital in London, U.K.
Giles's team used common laboratory analysis to examine COX-2, estrogen receptor (ER), progesterone receptor (PGR), HER-2, Ki67, and CD31 expression in 86 breast cancer tumors. The team reported its findings in Clinical Cancer Research.
"COX-2 protein expression was detected in 79% of all tumors studied, ER was detected in 79% of all tumors studied, PGR was detected in 73% of all tumors studied, and HER-2 was detected in 16% of all tumors studied," Davies and coworkers stated.
Of the many tumor elements analyzed, only CD31, an angiogenesis biomarker, ...
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Source: HighBeam Research, There may be a functional relationship between breast adenocarcinoma...