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Multiple suppressor genes may exist on the short arm of chromosome 8.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Multiple suppressor genes may exist on the short arm of chromosome 8. According to a study from Australia, "Loss of heterozygosity (LOH) of the short arm of chromosome 8 occurs frequently in breast tumors.
"Fine mapping of the smallest regions of overlap of the deletions indicates that multiple tumor suppressor genes may be located in this region. We have performed microcell-mediated chromosome transfer of chromosome 8 into two breast cancer cell lines, 21MT-1 and T-471)," wrote P. Wilson and colleagues, Queensland Institute of Medical Research, RBH PO.
"Twenty-two of the resulting hybrids were characterized extensively with chromosome 8 microsatellite markers and a subset were assayed for growth in vitro and soft agar clonicity," the researchers stated.
"There was no evidence in any of the hybrids for suppression of growth or clonicity that could be attributed to the presence of particular regions of chromosome 8; however, none of the 22 hybrids examined had taken up all of the donor chromosome 8, and in fact there were three regions that contained only one allele of the ...
- Candidate tumor suppressor genes at FRA7G do not suppress malignancy.
- Newspaper article from: Cancer Gene Therapy Week May 12, 2003 700+ words
...NewsRx.net) -- Candidate tumor suppressor genes at FRA7G do not suppress malignancy...site containing the candidate tumor suppressor genes CAV1, CAV2, and TESTIN (TES...CAV2, and TESTIN are not tumor suppressor genes in this gastric cancer," the researchers...
- Tumor suppressor genes in hepatocellular carcinoma have aberrant profiles.
- Newspaper article from: Health & Medicine Week October 13, 2003 700+ words
...com & NewsRx.net) -- Tumor suppressor genes in hepatocellular carcinoma have aberrant...Recent studies suggest that tumor suppressor genes (TSGs) can also be silenced through...promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J...
- Tumor suppressor genes can block leukemic cell proliferation.(Brief Article)
- Newspaper article from: Cancer Weekly March 5, 2002 700+ words
...Forcing leukemic cells to express tumor suppressor genes impairs their ability to proliferate...researchers in China report. "The tumor suppressor genes p53 and p16[superscript]INK4a...Transfecting leukemic cells with the tumor suppressor genes p53 and p16[superscript]INK4a...
- Arthritis suppressor genes TIA-1 and TTP vanquish arthritogenic cytokines.
- Newspaper article from: Gene Therapy Weekly April 8, 2004 700+ words
...amp; NewsRx.net) -- Arthritis suppressor genes TIA-1 and TTP vanquish arthritogenic...1 and TTP function as arthritis suppressor genes: TIA-1(-/-) mice develop mild...Academy of Sciences USA (Arthritis suppressor genes TIA-1 and TTP dampen the expression...
- Tumor suppressor genes can block leukemic cell proliferation.
- Newspaper article from: Blood Weekly March 7, 2002 700+ words
...Forcing leukemic cells to express tumor suppressor genes impairs their ability to proliferate...researchers in China report. "The tumor suppressor genes p53 and p16[superscript]INK4a...Transfecting leukemic cells with the tumor suppressor genes p53 and p16[superscript]INK4a...
- Tumor-Suppressor Genes Linked To Insulin Signaling.
- Newspaper article from: Genomics & Genetics Weekly June 22, 2001 700+ words
...insulin signaling and certain tumor suppressor genes that may lead to significant progress...between the tuberous sclerosis (TSC) suppressor genes and insulin signaling. Tuberous sclerosis...in either the TSC1 or TSC2 tumor-suppressor genes. The disease is characterized by...
- Candidate tumor-suppressor genes identified on chromosome arm 8p.
- Newspaper article from: Proteomics Weekly September 20, 2004 700+ words
...have identified potential tumor-suppressor genes on chromosome arm 8p in early-onset...is the site of one or more tumor-suppressor genes (TSGs). Comparative genomic hybridization...study in Oncogene (Candidate tumor-suppressor genes on chromosome arm 8p in early-onset...
- Restoration of metastasis suppressor genes could abate cancer dissemination.
- Newspaper article from: Gene Therapy Weekly November 4, 2004 700+ words
...net) -- Restoration of metastasis suppressor genes could abate cancer dissemination...group of genes, termed metastasis suppressor genes (MSG), encode for proteins that...in Anti - Cancer Drugs (Metastasis suppressor genes: a role for raf kinase inhibitor...