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Human breast cancer resistance protein may play a role in sterol transport.
2003 AUG 7 - (NewsRx.com & NewsRx.net) -- Human breast cancer resistance protein may play a role in sterol transport.
"The human breast cancer resistance protein (BCRP, also know as ABCG2, MXR, or ABCP) is one of the more recently discovered ATP-binding cassette (ABC) transporters that confer resistance on cancer cells by mediating multidrug efflux," scientists in England report.
"In the present study, we have obtained functional expression of human BCRP in the Gram-positive bacterium Lactococcus lactis. BCRP expression conferred multidrug resistance on the lactococcal cells, which was based on ATP-dependent drug extrusion," wrote T. Janvilisri and colleagues, Cambridge University, Department of Pharmacology.
"BCRP-mediated ATPase and drug transport activities were inhibited by the BCRP-specific modulator fumitremorgin C. To our knowledge these data represent the first example of the functional expression of a mammalian ABC half-transporter in bacteria," the researchers wrote.
"Although members of the ABCG subfamily (such as ABCG1 and ABCG5/8) have been implicated in the transport of sterols, such a role has not yet been established for BCRP," the researchers stated.
"Interestingly, the BCRP-associated ATPase activity in L. lactis ...
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Source: HighBeam Research, Human breast cancer resistance protein may play a role in sterol...