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Group B streptococcal vaccine candidates identified.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Novel protein vaccine candidates against Group B streptococcal infection have been identified using alkaline phosphatase fusions.
"Using an alkaline phosphatase-based genetic screening method, we identified a number of proteins that are potentially located on the outer surface of Group B streptococcus (Streptococcus agalactiae)," scientists in England report.
"In an enzyme-linked immunosorbent assay, antisera raised against two of the proteins, the streptococcal yutD homologue and a subunit of an ABC transporter, recognized clinically important serotypes of Group B streptococcus," stated Martin J. G. Hughes and collaborators at Microscience Ltd., Reading University, and Avecia LifeScience Molecules in the U.K. "In a neonatal rat model, purified IgG from the sera conferred significant levels of protection against a lethal challenge infection."
The researchers concluded, "The ...
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Source: HighBeam Research, Group B streptococcal vaccine candidates identified.