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Certain leukocyte IgG receptors affect immunity to Streptococcus pneumoniae.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Certain leukocyte IgG receptors affect vaccine-induced immunity to Streptococcus pneumoniae.
According to a study from the Netherlands and Iceland, "Members of the leukocyte immunoglobulin (Ig) G receptor (Fc-gamma-R) family play a key role in antibody-mediated phagocytosis and can either enhance antigen presentation or down-modulate immune responses. We studied immune responses to a pneumococcal conjugate (pneumococcal polysaccharide serotype 1 [PPS1]-tetanus toxoid) and antibody-mediated protection in mice deficient for individual Fc-gamma-Rs and complement receptor 3 (CR3)."
"FcR gamma chain-deficient (FcR gamma chain-/-) mice, which lack expression of both Fc-gamma-RI and III, had significantly lower anti-PPS1 IgG2b and IgG3 responses than did wild-type mice, whereas Fc-gamma-RII-deficient (Fc-gamma-RII-/-) mice had significantly higher IgG2a and IgG3 titers," reported Eirikur Saeland and colleagues at the University of Utrecht in the Netherlands and Landspitali-University Hospital in Iceland.
The authors continued, "Wild-type and Fc-gamma-RII-/- mice were protected against infection with pneumococcal serotype 1, whereas immunized FcR gamma ...
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Source: HighBeam Research, Certain leukocyte IgG receptors affect immunity to Streptococcus...