Rotavirus protein NSP4 induces antibody responses during natural infection.

2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Rotavirus nonstructural protein NSP4 induced heterotypic antibody responses during natural infection in children.

According to recent research from India, "Seroconversion of immunoglobulin A (IgA) and immunoglobulin G (IgG) (greater than or equal tofourfold rise) to rotavirus nonstructural protein 4 (NSP4) was determined, by use of enzyme-linked immunosorbent assay with fusion proteins glutathione S-transferase (GST)-NSP4 from strains SA11 (A), 116E (B), and RRV (C), in 40 children with acute rotavirus gastroenteritis and in 30 with the same disease due to other pathogens."

"The IgG seroconversion rates in the rotavirus group were 67.5%, 70%, and 60% when recombinant (r) NSP4A, -B, and -C, respectively, were used as antigen in the assay, and, for rotavirus-uninfected children, rates were 10%, 13%, and 7%," reported Pratima Ray and colleagues at the All India Institute of Medical Sciences.

"IgA seroconversion occurred in 57%, 70%, and 50%, respectively, of children with rotavirus gastroenteritis; in rotavirus-uninfected children, one child each seroconverted to the different rNSP4s. Among nine children infected with strain NSP4A, 7, 6, and 5 children showed IgG seroconversion, and, among 18 ...