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Cytokine response after measles challenge dependent on vaccine protein.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- The cytokine response after a measles virus challenge was dependent upon the type of protein used in the vaccine.
According to published research from the United States, "Measles is associated with a million deaths a year in developing countries because of secondary infections. Morbidity is particularly severe in young infants. Both measles-induced immune suppression and atypical measles have been associated with a type 2 cytokine bias of the immune response."
"The role of individual virus proteins in the induction of these cytokine responses is unknown and could be important for the development of new vaccines," said Fernando P. Polack and colleagues at Johns Hopkins University "We have used a rhesus macaque model and DNA vaccines to investigate cytokine responses to the individual measles virus (MV) protective antigens, hemagglutinin, and fusion. The hemagglutinin protein primed for a type 2 cytokine response, with suppression of interleukin (IL)-12 and preferential production of IL-4 after MV challenge. The fusion protein primed for a type 1 response with preferential production of interferon-gamma. Responses were ...
- Aerosol Delivery Of Transgenes Induces Transient Cytokine Response.
- Newspaper article from: Gene Therapy Weekly April 12, 2001 700+ words
...treatment of pulmonary disease induces a transient, localized cytokine response. "Pulmonary gene therapy with nonviral vectors delivered...DNA) complexes to mice in aerosol form and analyzed the cytokine response. Aerosol delivery of PEI-DNA complexes was localized...
- Deficiency results in low infection and increased inflammatory cytokine...
- Newspaper article from: Immunotherapy Weekly May 14, 2003 700+ words
...deficiency results in lower infection and increased inflammatory cytokine response. According to a study from France, "The BCL-2 family...results in lower infection and an increased inflammatory cytokine response associated with more severe pathology." Perfettini and...
- An inflammatory cytokine response occurs simply by virus-cell contact.
- Newspaper article from: Immunotherapy Weekly May 28, 2003 700+ words
2003 MAY 28 - (NewsRx.com & NewsRx.net) -- An inflammatory cytokine response is initiated by membrane receptors simply by contact with human cytomegalovirus. According to a study from the United States...
- The host cytokine response to porphyromonas gingivalis is modified by...
- Magazine article from: Life Extension July 1, 2009 700+ words
...result in high levels of IL-1beta but not the related secondary cytokines IL-6 and IL-8. We further demonstrate that cytokine response differences are the result of the action of P. gingivalis proteases, with lysine gingipain being the most effective...
- Monitor Toxicity, Anti-Cancer Drug Efficacy and Cytokine Response with New...
- Press release article from: Business Wire February 19, 2008 700+ words
...annual Screening Europe conference and exhibition. Whether monitoring chemical toxicity, anti-cancer drug efficacy or cytokine response, the CytoTox-Glo Assay provides a highly sensitive, simple, luminescent method that allows the user to detect small...
- Cytokine response to T. brucei infection characterized.
- Newspaper article from: Obesity, Fitness & Wellness Week June 26, 2004 700+ words
2004 JUN 26 - (NewsRx.com & NewsRx.net) -- The patterns of cytokine activity during Trypanosoma brucei infection have been characterized. According to recent research from Scotland, a "vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and
- Interorgan differences seen in cytokine response to Penicillium marneffei.
- Newspaper article from: AIDS Weekly March 3, 2003 700+ words
2003 MAR 3 - (NewsRx.com & NewsRx.net) -- "Penicillium marneffei is an intracellullar opportunistic fungus causing invasive mycosis in AIDS patients," according to a recent study from the University of Milan. "T cells and macrophages are important for protection in vivo. However, the role of
- Combination Therapy for Hepatitis B Increases T-Helper Cell, Cytokine Response.
- Newspaper article from: Immunotherapy Weekly Nichols, Sonia February 21, 2001 700+ words
2001 FEB 21 - (NewsRx.com & NewsRx.net) -- by Sonia Nichols, staff medical writer -- Combination drug therapy incorporating ribavirin and interferon (IFN)-alpha elicits long-term immune response in hepatitis B virus patients. T helper (Th) cells and Th1 cytokines are more likely to be detected