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Interferon resistance gene needed for modified vaccinia virus Ankara replication.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - Researchers in Germany have identified an interferon (IFN) resistance gene whose expression is critical for modified vaccinia virus Ankara (MVA) replication.
Highly attenuated MVA "serves as a candidate vaccine to immunize against infectious diseases and cancer," including HIV infection, explained Simone Hornemann and colleagues at Ludwig Maximilians University in Munich and the Technical University of Munich.
A mutant form of MVA lacking expression of the IFN resistance gene E3L was unable to replicate in chicken embryo fibroblasts (CEF) used in experimental tissue cultures, Hornemann and coauthors found.
The researchers developed an MVA deletion mutant dubbed MVA-deltaE3L. This mutant did not have the ability to grow in CEF, a functional loss that was reversed by reinsertion of the missing E3L gene, according to the report.
DNA replication of MVA-deltaE3L was seen during nonproductive CEF infection, but viral protein synthesis was incomplete and infected cells underwent rapid apoptosis, study data showed. In additon, CEF infected with mutant MVA produced high levels of interferon (IFN)-alpha ...
- Accidental infection of laboratory worker with vaccinia virus. (Dispatches).
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- Newspaper article from: Proteomics Weekly January 26, 2004 700+ words
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- Method developed to monitor immune response against vaccinia virus.
- News wire article from: Bioterrorism Week May 31, 2004 700+ words
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- Newspaper article from: Vaccine Weekly August 26, 2009 700+ words
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- Secondary and tertiary transfer of vaccinia virus among U.S. military...
- Newspaper article from: Morbidity and Mortality Weekly Report Barkdoll, TW Cabiad, RB Tankersley, MS Adkins, JL Jilly, B Herriford, G Whelen, AC Bell, CA Fairchok, MP Raynor, LC Garde, VA Rothmeyer, VM Mahlen, SD Engler, RJ Collins, LC Duran, LL Huynh, MT Bradshaw, RD Grabenstein JD February 13, 2004 700+ words
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- Magazine article from: BIOWORLD Today Leff, David N. May 16, 2000 700+ words
...A Phase I trial of a recombinant vaccinia virus expressing prostate-specific antigen...antigen molecule, so the vaccine in the vaccinia virus vector expresses the complete PSA sequence...dose, then gradually declined. No Vaccinia Virus Virgins Need Apply Another condition...
