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Expression of tumor antigens in acute leukemias investigated.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Expression of serologically identified tumor antigens in acute leukemias has been investigated.
According to published research from Germany, "Cancer/testis antigens (CTA) are an expanding family of immunogenic proteins selectively expressed in human neoplasms. As little is known about the expression of serologically identified CTA in leukemias so far, we investigated the expression of 5 CT genes (SSX-1, HOM-MEL-40/SSX-2, HOM-TES-14/SCP-1, SCP-3 and NY-ESO-1) in leukemic blood samples obtained from patients with either acute lymphatic leukemias (ALL) or myelocytic leukemia (AML)."
"RT-PCR-analyses showed no expression of any of the CT-genes in the leukemia samples of 19 patients with AML, whereas frequent expression was found in ALL," reported Philipp Niemeyer and collaborators at Saarland University and Johannes Gutenberg Universitat Mainz. "In the 17 ALL cases studied, SCP3a; SSX-1, HOM-MEL-40/SXX-2 and HOM-TES-14/SCP-1 were expressed in 47, 29, 29, and 12%, respectively, whereas no case was positive for NY-ESO-1. Sixty-five percent of patients with ALL showed expression of at least one, 41% of two or more of the five CT-genes investigated."
- 'Commercializing on Tumor Antigens: Analytical Perspectives'; - New 'de-novo'...
- Press release article from: PR Newswire May 14, 2002 700+ words
...a new report, "Commercializing On Tumor Antigens: Analytical Perspectives", that...report we have identified more than 60 tumor antigens that are in line for commercialization...an updated summary of the field of tumor antigens today, for example discussing the...
- Research and Markets: Commercializing on Tumor Antigens: Analytical...
- Press release article from: Business Wire July 14, 2004 700+ words
DUBLIN, Ireland -- Tumor Antigens Industry, Worth an Estimated...addition of Commercializing on Tumor Antigens: Analytical Perspectives to...analyst at a VC firm. More than 60 tumor antigens have been identified that are...
- Transfection of tumor antigens generates cytotoxic T lymphocytes.
- Newspaper article from: Biotech Week August 4, 2004 700+ words
...amp; NewsRx.net) -- Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged...study in Molecular Therapy (Transfection of RNA encoding tumor antigens following maturation of dendritic cells leads to prolonged...
- Regulatory T cells may have a role in poor immune response against tumor...
- Newspaper article from: Vaccine Weekly November 27, 2002 700+ words
...ELS, senior medical writer - The weak immunogenicity of tumor antigens may be due to regulatory T cells that suppress the response...and may partly explain the poor immune response against tumor antigens." The corresponding author for this study is David C...
- Regulatory T cells may have a role in poor immune response against tumor...
- Newspaper article from: Cancer Weekly November 26, 2002 700+ words
...ELS, senior medical writer - The weak immunogenicity of tumor antigens may be due to regulatory T cells that suppress the response...and may partly explain the poor immune response against tumor antigens." The corresponding author for this study is David C...
- RNA-transfected cells induce responses against viral and tumor antigens.
- Newspaper article from: Health & Medicine Week May 3, 2004 700+ words
...necessity of HLA matching," stated Christina M. Coughlin and colleagues at the University of Pennsylvania. "For viral and tumor antigens, CD40-B/RNA technology induced cytotoxic T lymphocytes (CTLs) from adults and children, which could be identified...
- Tumor antigens known to be immunogenic in man. (Research Report)
- Newspaper article from: Cancer Weekly Lloyd, K.O. March 1, 1993 700+ words
According to an abstract presented by the author to the Specific Immunotherapy of Cancer Vaccines Conference, held January 21-24, 1993, in Washington, D.C., "A limited number of tumor cell components have been shown to be immunogenic in cancer patients. Examples include melanoma glycoproteins and
- Human tumor antigens relevant for vaccine construction: an overview. (Research...
- Newspaper article from: Cancer Weekly Reisfeld, R.A. March 1, 1993 700+ words
According to an abstract presented by the author to the Specific Immunotherapy of Cancer Vaccines Conference, held January 21-24, 1993, in Washington, D.C., "Successful construction of anticancer vaccines requires thorough characterization of the immunogens, i.e., human tumor-associated antigens
- Identification of colon tumor antigens using T-cell proliferative responses...
- Newspaper article from: Cancer Weekly Pelle, B.A. Ransom, J.H. Pomato, N. Hanna, M.G. March 15, 1993 700+ words
AUTHORS: B.A. Pelle, J.H. Ransom, N. Pomato and M.G. Hanna. Organon Teknika/Biotechnology Research Institute, Rockville, Maryland. According to an abstract presented by the authors to the Specific Immunotherapy of Cancer Vaccines Conference, held January 21-24, 1993, in Washington, D.C., "Ten colon
- Method for identifying new tumor antigens developed.
- Newspaper article from: Genomics & Genetics Weekly April 4, 2003 700+ words
2003 APR 4 - (NewsRx.com & NewsRx.net) -- GeneMax Corp. (GMXX; GX1) announced that it has added to its technology portfolio by expanding the license with the University of British Columbia in Vancouver, Canada. The added technology, developed under the Collaborative Research Agreement between
Source: HighBeam Research, Expression of tumor antigens in acute leukemias investigated.