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Novel adenovirus-based SIV vaccine effective in macaques.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- by Michael Greer, senior medical writer - A novel adenovirus-based vaccine against the simian version of HIV (SIV) has delivered promising results in a macaque model of infection, researchers in the United States report.
Jun Zhao and colleagues at the National Cancer Center in Bethesda, Maryland, the Duke University Medical Center in Durham, North Carolina, and Advanced BioScience Laboratories, Inc., in Kensington, Maryland "investigated the ability of a replication-competent Ad5hr-SIVenv/rev and Ad5hr-SIVgag recombinant priming/gp120 boosting regimen to induce protective immunity in rhesus macaques against pathogenic simian immunodeficiency virus[subscript]mac251."
Although it did not completely protect against infection, this regimen produced robust cellular and humoral anti-SIV immune activity, Zhao and coauthors found.
All of the immunized animals developed SIV-neutralizing serum antibodies, with immunoglobulin G (IgG) and IgA antibodies targeting the SIV coat protein gp120 seen in secretory fluids, the researchers said. Vaccinated animals also showed anti-SIV T-cell activity for more than 10 months after treatment.
While all of the immunized macaques became infected with SIV after challenge, 8 of 12 animals had significantly reduced viremia compared to controls, study data indicated. None of these eight macaques carried Mamu-A*01, a major histocompatibility complex (MHC) ...
- Novel adenovirus-based SIV vaccine effective in macaques.
- Newspaper article from: Biotech Week August 6, 2003 700+ words
...senior medical writer - A novel adenovirus-based vaccine against...simian version of HIV (SIV) has delivered promising...confer protection against SIV. Nonneutralizing IgG...study include: 1) A novel adenovirus-based vaccine against...simian version of HIV (SIV) has delivered ...
- Novel adenovirus recombinant HIV-1 vaccine shows promise in murine study.
- Newspaper article from: Gene Therapy Weekly May 29, 2003 700+ words
...and Opportunistic Infections that they've developed a novel adenovirus recombinant HIV-1 vaccine. Tests of the vaccine in mice...and colleagues titled their conference presentation, "A novel adenovirus recombinant vaccine to HIV-1." The information in this...
- Isolation of novel adenovirus from fruit bat (Pteropus dasymallus...
- Magazine article from: Emerging Infectious Diseases Maeda, Ken Hondo, Eiichi Terakawa, Junpei Kiso, Yasuo Nakaichi, Numekazu Endoh, Daiji Sakai, Kouji Morikawa, Shigeru Mizutani Tetsuya February 1, 2008 700+ words
...persistently infect bats. In the process, we isolated a novel adenovirus from a fruit bat in Japan. Pteropus dasymallus yayeyamae...isolation of DNA virus is rare (1). The isolation of the novel adenovirus seems to be possible because of usage of the primary cells...
- Novel Adenovirus Targets Ca Tumors.(cancer)
- Magazine article from: Family Practice News ZOLER, MITCHEL L. May 1, 1999 700+ words
PHILADELPHIA -- Treatment with a genetically engineered adenovirus that infects only tumor cells safely eradicated head and neck cancers from six patients in a phase II study with 26 patients. The tumors were reduced by more than half in another 10 patients. This response was "way better than what
- Novel Adenovirus Vectors Harbored 100K Gene Deletions.
- Newspaper article from: Gene Therapy Weekly August 16, 2001 700+ words
2001 AUG 16 - (NewsRx.com & NewsRx.net) -- by Deborah W. Heinrich, PhD, staff medical writer - New adenovirus vectors with deletions that inactivate the 100K gene hold promise for enhanced transgene expression, without the late phase-associated problems, in various gene therapy applications,
- Siv, Sichan: Golden Bones: An Extraordinary Journey from Hell in Cambodia to a...
- Magazine article from: Asian Affairs: An American Review Chai, May-Lee June 22, 2009 700+ words
Siv, Sichan Golden Bones: An Extraordinary Journey...34068-0 Publication Date: July 2008 Sichan Siv's memoir is being marketed as a traditional...immigrant story, celebrating the opportunity Siv found in the United States after fleeing the...
- SIV market grows, so do SIV-lites'.
- Newspaper article from: Asset Securitization Report Mitchell, Donna August 21, 2006 700+ words
Structured investment vehicles (SIV) take a long time to put together and require delicate...prompting market players to draw distinctions between the SIV structure and their spin offs, SIV-lites.' "These recently coined SIV-lites, have...
- Live-attenuated SIV expressing interleukin-4 stimulate immune response.
- Newspaper article from: Vaccine Weekly April 2, 2003 700+ words
...response in macaques. According to recent research from Germany, "Nef deletion mutants of SIV-expressing interleukin-4 (SIV-IL4) or interferon-gamma (SIV-IFN) were constructed to study the effect of interferon-gamma (IFN-gamma) and...
