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Antibodies elicited by 11-valent pneumococcal vaccine.

Vaccine Weekly

| August 06, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 AUG 6 - (NewsRx.com & NewsRx.net) -- Functional antibodies were stimulated by an 11-valent diphtheria-tetanus toxoid-conjugated pneumococcal vaccine.

According to a study from Finland and the Philippines, "The aluminum-adjuvanted 11-valent pneumococcal conjugate vaccine containing polysaccharides 1, 4, 5, 7F, 9V, 19F, and 23F (coupled to tetanus protein) and polysaccharides 3, 6B, 14, and 18C (coupled to diphtheria toxoid) elicits high antibody concentrations in Filipino infants when given at ages 6, 10, and 14 weeks and 9 months simultaneously with the national vaccination program."

"We evaluated functional activity of these antibodies by using a viable cell opsonophagocytic assay (OPA)," reported Taneli Puumalainen and collaborators at National Public Health Institute of Finland and the Research Institute for Tropical Medicine in the Philippines. "The OPA titers correlated (r=0.53-0.74) with the respective antibody concentrations. The geometric mean OPA titers after three vaccine doses were 276.9 (serotype 4), 12.3 (serotype 6B), 46.0 (serotype 14), 119.3 (serotype 19F), and 206.3 (serotype 23F). The ...

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Source: HighBeam Research, Antibodies elicited by 11-valent pneumococcal vaccine.

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