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DNA vaccines enhance cellular immune response to SIV Gag.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- An enhanced cellular immune response against SIV Gag was induced by immunization with DNA vaccines expressing assembly and release-defective SIV Gag proteins.
"Codon-optimized genes were synthesized for the SIVmac239 Gag, a mutant Gag with mutations in the major homology region, and a chimeric Gag containing a protein destruction signal at the N-terminus of Gag," scientists in the United States report.
"The mutant and chimeric Gag were expressed at levels comparable to that observed for the wild-type Gag protein but their stability and release into the medium were found to be significantly reduced," said Zhigao Bu and colleagues at Emory University in Atlanta. "Immunization of mice with DNA vectors encoding the mutant or chimeric Gag induced fourfold higher levels of anti-SIV Gag CD4 T cell responses than the DNA vector encoding the wild-type SIV Gag. Moreover, anti-SIV Gag CD8 T cell responses induced by DNA vectors encoding the mutant or chimeric Gag were found to be 5- to 10-fold higher than those induced by the DNA construct for ...
- SIV Gag DNA vaccines exhibit enhanced immunogenicity.
- Newspaper article from: Drug Week December 19, 2003 700+ words
...com & NewsRx.net) -- SIV Gag DNA vaccines encoding chimeric proteins containing...immune responses against the SIV Gag antigen in the context of DNA...Enhanced immunogenicity of SIV Gag DNA vaccines encoding chimeric proteins containing...
- DNA vaccines enhance cellular immune response to SIV Gag.
- Newspaper article from: Health & Medicine Week August 4, 2003 700+ words
...immune response against SIV Gag was induced by immunization with DNA vaccines expressing assembly and release-defective SIV Gag proteins. "Codon...immune response against SIV Gag induced by immunization with DNA vaccines expressing assembly...
- SIV gag DNA-Vaccinated Monkeys Develop Protective Immune Responses.(simian...
- Newspaper article from: Vaccine Weekly September 20, 2000 700+ words
...with a simian immunodeficiency virus (SIV) gag DNA vaccine developed protective immune...lymphocyte responses to a dominant SIV Gag epitope in genetically selected rhesus monkeys, a codon-optimized SIV gag DNA vaccine construct was shown to...
- SIV gag DNA-Vaccinated Monkeys Develop Protective Immune Responses.
- Newspaper article from: AIDS Weekly September 18, 2000 700+ words
...with a simian immunodeficiency virus (SIV) gag DNA vaccine developed protective immune...lymphocyte responses to a dominant SIV Gag epitope in genetically selected rhesus monkeys, a codon-optimized SIV gag DNA vaccine construct was shown to...
- Vaccinia virus DIs expressing SIV gag controls SHIV in monkeys.
- Newspaper article from: Drug Week February 6, 2004 700+ words
...vaccinia virus DIs expressing simian immunodeficiency virus (SIV) gag controls highly pathogenic SHIV in monkeys. "To be effective...interferon (IFN-gamma) spot-forming cells (SFC) specific for SIV Gag," scientists in Japan report. "Antigen-specific lymphocyte...
- DNA Vaccines (HIV) "SIV-Specific Cytotoxic T Lymphocytes Induced by DNA...
- Newspaper article from: Gene Therapy Weekly October 12, 1998 700+ words
...autologous cells infected with recombinant vaccinia virus expressing SIV Gag-Pol and Env, expanded in IL-2, and tested for lytic activity...However, after only 2 DNA immunizations, CD3(+)CD8(+) SIV Gag-specific T cell clones could be obtained. The clones were...
- Reportlinker Adds DNA Vaccines: Technologies and Global Markets.(Company...
- Press release article from: Business Wire September 24, 2009 700+ words
...in its catalogue. Reportlinker Adds DNA Vaccines: Technologies and Global Markets http...com/p0148904/Reportlinker-Adds-DNA-Vaccines-Technologies-and-Global-Markets...interest is to analyze and quantify the DNA vaccines market potential by disease type, end...
- Beta-actin promoter plus regulatory element enhances efficacy of DNA vaccines.
- Newspaper article from: Genomics & Genetics Weekly August 27, 2004 700+ words
...regulatory element enhances the protective efficacy of DNA vaccines. "DNA vaccines represent a novel and powerful alternative to...produced en masse at low cost; more importantly, DNA vaccines against emerging pathogens or bioterrorism threats...
