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Naked plasmid DNA injection into solid tumors of mice characterized.
2003 AUG 6 - (NewsRx.com & NewsRx.net) -- A team of researchers in Japan has characterized the disposition and gene expression in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice.
"Previous studies have suggested that direct injection of naked plasmid DNA (pDNA) into solid tumors can be a useful method for in vivo gene transfer into tumor cells. To gain more insight into this approach, we studied the disposition and gene expression characteristics of naked pDNA after intratumoral injection by direct comparison with those after intramuscular injection in mice," scientists writing in the Journal of Pharmaceutical Sciences report.
"pDNA encoding reporter genes were directly injected into subcutaneous solid tumor models and skeletal muscles," said Atsushi Kawase and colleagues at Kyoto University. "Biodistribution studies using radiolabeled pDNA showed that the elimination of pDNA from the injection site was relatively fast and a part of the pDNA was absorbed from the lymphatic system after both local injections. Confocal microscopic studies using fluorescein-labeled pDNA demonstrated that pDNA distributed efficiently throughout the muscle tissue whereas pDNA localization in the tumor tissue was restricted."
"Characterization of gene expression clarified the variation in expression level between tumor preparations and some ...
- Naked plasmid DNA injection into solid tumors of mice characterized.
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