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A mosaic virus strategy may improve adenoviral tropism in human gene therapy.

Drug Week

| August 01, 2003 | COPYRIGHT 2009 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 AUG 1 - (NewsRx.com & NewsRx.net) -- A mosaic virus strategy may improve adenoviral tropism in human gene therapy.

According to published research from the United States, "the efficiency of cancer gene therapy with recombinant adenoviruses based on serotype 5 (Ad5) has been limited partly because of variable, and often low, expression by human primary cancer cells of the primary cellular-receptor which recognizes the knob domain of the fiber protein, the coxsackie and adenovirus receptor (CAR). As a means of circumventing CAR deficiency, Ad vectors have been retargeted by utilizing chimeric fibers possessing knob domains of alternate Ad serotypes."

"We…

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Source: HighBeam Research, A mosaic virus strategy may improve adenoviral tropism in human gene...

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