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Hot proteins may sharpen DNA tests; help bioprocessing.
2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Unique heat shock proteins that protect bacteria in undersea hot vents could be used to improve the sensitivity of polymerase chain reaction (PCR), the common technique used to amplify bits of DNA for medical and forensic sciences, say researchers with the University of Maryland Biotechnology Institute (UMBI).
In addition, commercial manufacturing of vaccines, antibiotics, and other medically important proteins could become more efficient by incorporating the unique heat shock proteins into microbial cells in those processes. Future use of the proteins could also impact agriculture, fish production, and other commercially important biological processes.
The findings were reported in the journal Extremophiles.
"Microorganisms that live in deep ocean vents where water exceeds the normal boiling point possess a phenomenal capacity for resisting heat damage," says Frank Robb of UMBI's Center of Marine Biotechnology (COMB). When temperatures rise above 103 degrees C, they form heat shock proteins that work as chaperones of key proteins in the cell, protecting and allowing them to remain intact at very high temperatures.
Similar chaperone proteins appear in all branches of ...
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Source: HighBeam Research, Hot proteins may sharpen DNA tests; help bioprocessing.