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Anti-A-beta antibodies reduce beta-amyloid deposition.
2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Intracranially administered anti-A-beta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.
According to recent research published in the Journal of Neuroscience, "Active immunization against the beta-amyloid peptide (A-beta) with vaccines or passive immunization with systemic monoclonal anti-A-beta antibodies reduces amyloid deposition and improves cognition in APP transgenic mice. In this report, intracranial administration of anti-A-beta antibodies into frontal cortex and hippocampus of Tg2576 transgenic APP mice is described."
"The antibody injection resulted initially in a broad distribution of staining for the antibody, which diminished over 7 days," reported Donna M. Wilcock and collaborators at the University of South Florida in the United States. "Although no loss of immunostaining for deposited A-beta was apparent at 4 hours, a dramatic reduction in the A-beta load was discernible at 24 hours and was maintained at three and seven days. A reduction in the thioflavine-S-positive compact plaque load was delayed until three days, at which time microglial activation also became apparent."
"At one week after the injection, microglial activation returned to control levels, whereas A-beta and thioflavine-S staining remained reduced," said Wilcock and her ...
- Microglial activation facilitates A-beta plaque removal.
- Newspaper article from: Drug Week April 9, 2004 700+ words
...NewsRx.net) -- Microglial activation facilitates A...which anti-A-beta antibodies clear amyloid...antibody-induced microglial activation with anti-inflammatory...suggest that microglial activation is necessary...
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...Brain cholinergic pathway regulates microglial activation through nAChR. According to recent...in the brain that could regulate microglial activation." Shytle continued, "Here we...cholinergic pathway that regulates microglial activation through alpha7 nicotinic receptors...
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- Silymarin protects dopaminergic neurons by inhibiting microglial activation.
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- A-beta antibodies may prevent Alzheimer disease plaque formation.
- Newspaper article from: Pain & Central Nervous System Week February 10, 2003 700+ words
...AD), amyloid beta-protein (A-beta) antibodies generated by A-beta peptide immunization...School. "B6D2F1 mice generated A-beta antibodies earlier and in higher quantities than...indicated that the mouse anti-A-beta antibodies recognize residues within A-beta1...
- Bovine IL-1[beta] antibodies.(NEW Technology)
- Magazine article from: Bioscience Technology May 1, 2005 700+ words
Unlabeled and biotin-labeled bovine IL-1[beta] antibodies polyclonal antibodies are offered by Pierce Biotechnology under its Endogen brand. They are validated as capture and detection...
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...Technology plc said Thursday it and Genzyme General took the lead in the race to develop and commercialize antibodies for TGF-beta, antibodies that could have therapeutic values ranging from cancer to fibrosis to wound closure. Their broad collaboration to develop...
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- Newspaper article from: Pain & Central Nervous System Week April 27, 2009 700+ words
...Alzheimer patients. At least 4 distinct actions of anti-A beta antibodies have been proposed as contributing to the inhibition of...present. Evidence is presented supporting arguments that microglial activation does play a role in amyloid removal, particularly compacted...
Source: HighBeam Research, Anti-A-beta antibodies reduce beta-amyloid deposition.