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H. pylori outer membrane antigens protective in guinea pigs.

Vaccine Weekly

| July 16, 2003 | COPYRIGHT 2003 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan.  All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)Copyright

2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Helicobacter pylori outer membrane antigens were protective in guinea pigs.

According to recent research published in the journal FEMS Immunology and Medical Microbiology, "Mice and guinea Pigs were intranasally immunized with either recombinant lipoprotein 20 or Helicobacter pylori outer membrane vesicles (OMV). Cholera toxin was used as mucosal adjuvant."

"In mice, both vaccines elicited systemic and local IgG responses, which correlated with significantly lower levels of H. pylori colonization," reported Jacqueline I. Keenan and collaborators at Christchurch School of Medicine and Health Sciences in New Zealand and the National Institute for Biological Standards and Control in the U.K. "In contrast, only OMV proved immunogenic in guinea pigs, with the development of both systemic and local immune responses. These antibodies did not, however, correlate with protection in these animals, which suggests that vaccine formulation is as important as ...

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Source: HighBeam Research, H. pylori outer membrane antigens protective in guinea pigs.

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