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Listeria HIV gag immunization induces antigen-specific T cell response.
2003 JUL 16 - (NewsRx.com & NewsRx.net) -- Immunization with recombinant Listeria monocytogenes HIV gag induced HIV gag-specific CD8+ T cells in the spleen and gut-associated lymphoid tissue.
According to recent research published in the Journal of Immunology, "The induction of mucosal immunity is crucial in controlling viral replication during HIV infection. In this study we compare the ability of a recombinant Listeria monocytogenes that expresses and secretes the HIV Ag Gag to induce CD8+ T cells against this antigen in the spleen, mesenteric lymph nodes, and Peyer's patches, and the ability to provide effector Gag-specific CD8+ T cells to the lamina propria after i.v., oral, or rectal administration of the vaccine."
"The levels of antigen-specific CD8+-activated T cells were measured ex vivo using intracellular cytokine staining for IFN-gamma and H-2K[superscript]d Gag peptide tetramer staining," reported Christian Peters and colleagues at the University of Pennsylvania in the United States. "We found that all routes of immunization induced Gag-specific CD8+ T cells in the spleen. After secondary infection, we observed substantial increases in splenic levels of CD8+ T cells, and levels of Gag-specific cells were similar to those against listeriolysin O, the immunodominant antigen of L. monocytogenes."
The researchers found, "Both primary and secondary oral immunization resulted in abundant Gag-specific CD8+-activated T cells in the lamina propria that constituted approximately 35% of the CD8 compartment. However, ...
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Source: HighBeam Research, Listeria HIV gag immunization induces antigen-specific T cell...