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Contraceptive potential of plasmid pCMV4-rZPC' DNA vaccine evaluated.
2003 JUL 16 - (NewsRx.com & NewsRx.net) -- The contraceptive potential of a plasmid pCMV4-rZPC' DNA vaccine has been evaluated.
"Zona pellucida C (ZPC) is a major glycoprotein of the zona pellucida that possesses the sperm receptor function. ZPC induces autoantibody that can block sperm/oocyte interaction. We selected the partial sequence of rabbit ZPC (amino acid 263-415, rZPC') as the target and constructed the pCMV4r-ZPC' gene vaccine by using DNA recombinant techniques," scientists in China report.
"The total RNA was extracted from the ovaries of the sexually healthy female rabbit, and the rZPC' cDNA, which was amplified by reverse transcription-polymerase chain reaction, was directly inserted into the cloning vector PCR2.1 to construct the PCR2.1-rZPC'," wrote Ruo-Lan Xiang and coauthors at the Chinese Academy of Sciences in Beijing. "This insertion fragment was subcloned into the pCMV4 vector to form the pCMV4-rZPC' prototype DNA vaccine. All experimental BALB/C mice and New Zealand rabbits received i.m. injection of pCMV4-rZPC' vaccine three times."
"The results show that: 1) the pCMV4-rZPC' construct expresses rZPC' cDNA in mice muscle cells; 2) 60% of the immunized female mice were infertile at six weeks after the immunization; 3) the mice immunized with pCMV4-rZPC' DNA vaccine ...
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Source: HighBeam Research, Contraceptive potential of plasmid pCMV4-rZPC' DNA vaccine evaluated.