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Mucosal and systemic vaccination with vaccinia virus Ankara immunogenic.
2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Both mucosal and systemic vaccination with the Ankara strain of vaccinia virus (MVA) stimulated strong immune responses in mice.
According to a study from Spain and Switzerland, "MVA is a candidate vector for vaccination against pathogens and tumors. Little is known about its behavior in mucosal tissues. We have investigated the fate and biosafety of MVA, when inoculated by different routes in C57BL/6 mice."
"Intranasal inoculation targeted the virus to the nasal associated lymphoid tissue and the lungs, whereas systemic inoculation led to distribution of MVA in almost all lymphoid organs, lungs, and ovaries," reported J. C. Ramirez and collaborators at Centro Nacional de Biotecnologia in Spain and the University of Lausanne in Switzerland. "Intravaginal, intrarectal, and intragastric inoculations failed to induce efficient infection. After 48 hours, no virus was detectable any more in the organs analyzed. Upon intranasal inoculation, no inflammatory reactions were detected in the central nervous system as well as the upper and ...
- Further European MVA patent for Bavarian Nordic.(modified vaccinia virus...
- Newspaper article from: Pharma Marketletter July 16, 2007 700+ words
...intellectual property position on Modified vaccinia virus Ankara (MVA) in Europe. The new patent...European Patent is directed to MVA which abortively infects neonates...our growing patent position on MVA also in Europe and adds further...
- Canada's DND requests proposal for MVA pox vaccs.(Department of National...
- Newspaper article from: Pharma Marketletter April 16, 2007 700+ words
...the acquisition of modified vaccinia virus Ankara-based smallpox vaccine...important as it illustrates that MVA-based smallpox vaccines are...a smallpox outbreak, noted MVA small pox vaccine firm Bavarian...government for 20 million doses of MVA-based smallpox vaccine, which...
- Method developed to monitor immune response against vaccinia virus.
- Newspaper article from: Virus Weekly June 1, 2004 700+ words
...neutralizing antibodies to vaccinia virus is measured using...based on a modified vaccinia virus Ankara (MVA) vector expressing...highly attenuated MVA eliminates the safety...replication-competent vaccinia virus in the standard clinical...
- Vaccinia virus K1L gene product inhibits host NF-kappa B activation.
- Newspaper article from: Health & Medicine Week May 24, 2004 700+ words
...net) -- The vaccinia virus K1L gene product...degradation. "Vaccinia virus wild-type strains...the attenuated MVA strain, whose...Moreover, MVA/K1L gained the...Virology (The vaccinia virus K1L gene product...
- Modified vaccinia virus elicits antibodies to cytomegalovirus strains.
- Newspaper article from: Biotech Week June 16, 2004 700+ words
...attenuated poxvirus, modified vaccinia virus Ankara (MVA), has been constructed to...Remarkably, pre-existing MVA and vaccinia virus (poxvirus) immunity did not...subsequent immunizations of gB680-MVA." The investigators concluded...
- New findings from J. Delaloye and co-authors describe advances in vaccinia...
- Newspaper article from: AIDS Vaccine Week October 5, 2009 700+ words
"Modified vaccinia virus Ankara (MVA) is an attenuated...report (see also Vaccinia Virus). "Here we report...immune sensing of MVA and cytokine responses...Sensing of Modified Vaccinia Virus Ankara (MVA) Is Mediated by TLR2...
- Research reports from G. Dilullo and co-authors provide new insights into...
- Newspaper article from: Vaccine Weekly May 20, 2009 700+ words
"Modified Vaccinia Virus Ankara (MVA) is employed...restoration in MVA of the deleted...report (see also Vaccinia Virus). "Recombinant...free recombinant MVA and increases...recombinant Modified Vaccinia Virus Ankara production...
- Vaccinia virus expressing RSV genes does not predispose for immunopathology.
- Newspaper article from: Biotech Week April 28, 2004 700+ words
...recombinant modified vaccinia virus Ankara expressing...recombinant modified vaccinia virus Ankara (MVA) vector expressing...improved by using MVA in a prime-boost...recombinant modified vaccinia virus Ankara expressing...
Source: HighBeam Research, Mucosal and systemic vaccination with vaccinia virus Ankara...