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Casein phosphopeptide enhances mucosal IgA response to Salmonella LPS.
2003 JUL 9 - (NewsRx.com & NewsRx.net) -- A dietary casein phosphopeptide preparation stimulated the mucosal IgA response of mice to an orally ingested lipopolysaccharide from Salmonella typhimurium.
"The effect on immunoglobulin production of a commercially available casein phosphopeptide preparation (CPP-III) consisting mainly of bovine alpha-s2-casein (1-32) and beta-casein (1-28) in mice that had orally ingested lipopolysaccharide (LPS) from Salmonella typhimurium was investigated," scientists in Japan report.
"No significant difference in body weight gain was observed between the mice fed on the CPP-III-added diet and those fed on the control diet," said Hajime Otani and colleagues at Shinshu University. "The mice fed on the CPP-III-added diet exhibited similar serum and intestinal IgG, IgM, and IgE responses towards LPS to those fed on the control diet, In contrast, fecal and intestinal anti-LPS IgA and total IgA in mice fed on the CPP-III-added diet were significantly higher than in those fed on the control diet. Spleen cells from mice fed on the CPP-III-added diet produced larger amounts of IgA, IL-5, and IL-6 than cells from mice fed on the control diet."
"These results suggest that ...
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Source: HighBeam Research, Casein phosphopeptide enhances mucosal IgA response to Salmonella LPS.