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Immunodominant epitopes found in tat-vaccinated volunteers.
2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Immunodominant epitopes have been identified in inactivated tat-vaccinated healthy and HIV-1-infected volunteers.
According to a study from Italy and France, "We analyzed the epitopes and the molecular forms of Tat recognized by the antibodies raised by Tat-toxoid vaccination in both healthy and HIV-infected volunteers."
"Tat-toxoid-vaccinated healthy volunteer sera reacted predominantly with peptides covering amino acids 1 through 24 and 46 through 60, corresponding to the N-terminus and basic domains of Tat," reported Douglas M. Noonan at the Istituto Nazionale per la Ricerca sul Cancro in Italy and collaborators in Italy and France. "In contrast, whereas all sera from vaccinated HIV-1-positive patients reacted with the N-terminus and (with a single exception) with the basic domain, most of these sera also recognized peptides encompassing distinct domains of Tat, particularly the C-terminus (79-86).
"The sera of vaccinated individuals recognized both monomeric and oligomeric forms of Tat 1 through 86 or of Tat 1 through 101 and also blocked the ability of cell-released extracellular Tat to transactivate the HIV-1 LTR promoter. Synthetic Tat preincubated with sera from vaccinated ...
- Immunoglobulin Deficiency Syndromes
- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Longe, Jacqueline January 1, 2006 700+ words
Immunoglobulin Deficiency Syndromes Definition Immunoglobulin deficiency syndromes are a group of immunodeficiency disorders...infectious diseases, people with immunoglobulin deficiency syndromes become ill more often. However, the cellular...
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- Encyclopedia entry from: Gale Encyclopedia of Medicine, 3rd ed. Polsdorfer, J. January 1, 2006 700+ words
Polyglandular Deficiency Syndromes Definition Polyglandular deficiency syndromes are disorders characterized by the failure...and symptoms The cause of polyglandular deficiency syndromes is usually an autoimmune response —...
- Gene for Immune Deficiency Syndromes Found; Finding May Yield New Test to...
- News wire article from: Ascribe Higher Education News Service July 10, 2005 700+ words
Byline: Children's Hospital Boston BOSTON, July 10 (AScribe Newswire) -- A newly discovered gene mutation may account for many cases of immune deficiency, in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the
- Immunodominant epitopes found in tat-vaccinated volunteers.
- Newspaper article from: AIDS Weekly July 7, 2003 700+ words
...These data demonstrate that Tat-toxoid vaccination induces...the functional activity of Tat." Noonan and his coauthors...Journal of Acquired Immune Deficiency Syndromes (Identification of immunodominant epitopes in inactivated tat-vaccinated healthy and HIV...
- Tats
- Encyclopedia entry from: Encyclopedia of World Cultures Volkova, Natalia; Testen, David January 1, 1996 700+ words
...Jewish community (whose native language is Tat), who had registered as Tats. The Tats have not only been assimilated...including the speech of the Armeno-Tats) and "Jewish Tat." The majority of Tats also know Russian, as well as the Azerbaijani...
- Tat protein elicits production of neutralizing antibodies.
- Newspaper article from: Virus Weekly December 14, 2004 700+ words
2004 DEC 14 - (NewsRx.com & NewsRx.net) -- The Tat protein or synthetic Tat peptide combination elicits the production of neutralizing antibodies. "The Tat regulatory protein of human immunodeficiency virus type 1 (HIV-1...
- Tat inhibitors, a new approach: interview with Olaf Kutsch, Ph.D.(Interview)
- Newspaper article from: AIDS Treatment News James, John S. January 28, 2005 700+ words
...developed an experimental drug that blocked the HIV protein Tat in laboratory tests. But it did not work against HIV...Despite over 2,500 scientific publications on the HIV tat gene or Tat protein, the knowledge was not translated into practical...
- TAT Cascades Licensed by Motorola.
- Press release article from: PR Newswire December 7, 2007 700+ words
MALMOE, Sweden, December 7 /PRNewswire/ -- TAT today announced that Motorola has signed an agreement to license the TAT Cascades user interface framework for use on select mobile devices. TAT Cascades is a UI technology that enables the creation...
