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Dengue virus NS1, NS2A, NS3, and NS5 mutant proteins restrict replication.
2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Temperature-sensitive mutations in the genes encoding the NS1, NS2A, NS3, and NS5 nonstructural proteins of dengue virus type 4 restricted replication in the brains of mice.
"Using reverse genetics, it is possible to readily add well-defined attenuating mutations to the genome of wild type or incompletely attenuated dengue (DEN) viruses to generate vaccine candidates that exhibit the desired balance between attenuation and immunogenicity," scientists in the United States report.
"Here, we describe the identification of eight temperature sensitive missense mutations distributed in four non-structural protein genes that specify a 60- to 10,000-fold range of restricted replication in the suckling mouse brain compared to wild type recombinant DEN4 virus," stated Joseph E. Blaney Jr and collaborators at the National Institute of Allergy and Infectious Diseases. "The usefulness of such mutations in flavivirus vaccine design and ...
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...have advanced the understanding of infectious diseases, joining an esteemed group of past...research. The National Foundation for Infectious Diseases awarded the honor to Richard P...leaders. As a leader in the field of infectious diseases, Wenzel has helped shape guidelines...
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