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Gamma-inulin/liposomes/vitamin E adjuvant used in contraceptive vaccines.
2003 JUL 9 - (NewsRx.com & NewsRx.net) -- A combination adjuvant composed of gamma-inulin, liposomes, and vitamin E promoted the formation of antibodies against sperm.
"The adjuvanticity of two gamma inulin/liposomes/vitamin E combinations was evaluated in the mouse, in contraceptive vaccines with sperm protein extracts or a synthetic HE2 peptide (human epididymis gene product; residues 15-28) as antigen. The HE2 peptide was not conjugated to a protein carrier, to ensure that the antibodies elicited were specific against the HE2 peptide," scientists in Spain report.
"The adjuvant combinations were designed to increase adjuvanticity, as their components have complementary mechanisms, and their performance was compared to Freund's adjuvant," said Pilar Fuentes and collaborators at the Universidad Autonoma de Barcelona. "Antibody production against native sperm structures was determined in sera by ELISA immunoassay and immunohistology. Toxicity of adjuvants was determined by histopathological study and treated mice were monitored for signs of pain or distress. Our results show that the gamma inulin (1-2 micrometer particle size)/liposomes/vitamin E combination, with sperm protein extracts, is better than ...
- Contraceptive vaccines based on mouse sperm protein PH20 assessed.
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Source: HighBeam Research, Gamma-inulin/liposomes/vitamin E adjuvant used in contraceptive...