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Intradermal injection enhances immunogenicity and suppresses tumorigenicity.
2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Intradermal injection, as opposed to subcutaneous injection, enhanced immunogenicity and suppressed tumorigenicity of tumor cells.
"Tumor cell immunogenicity depends heavily upon the microenvironment in which the cells grow. We have compared the tumorigenicity and immunogenicity of the same tumor cells when injected either into the dermis, a tissue containing numerous dendritic cells (DCs), or s.c. at a site which contains only few DCs," scientists in the United States and France report.
"After s.c. injection, progressive tumors were constantly obtained, whereas most intradermal injections did not give rise to tumor and immunized animals against additional challenge," said Bernard Bonnotte and collaborators at the Mayo Clinic in the United States and INSERM U517 in France. "We present evidence that the high density of DCs at dermal sites facilitates the capture of ...
- Karo Bio receives award for prostate cancer research.(United States provides...
- Newspaper article from: Nordic Business Report March 12, 2002 700+ words
NORDIC BUSINESS REPORT-12 March 2002-Karo Bio receives award for prostate cancer research (C)1994-2002 M2 COMMUNICATIONS LTD http://www.m2.com The Swedish pharmaceutical company Karo Bio AB has received a...
- Yorkshire Cancer Research obtains United States patent.(on DNA coding for...
- Newspaper article from: BIOTECH Patent News November 1, 2001 700+ words
Yorkshire Cancer Research (North Yorkshire, England) has patented isolated DNA coding for canine p53 protein, along with vectors and host cells containing...
- Sloan-Kettering Institute for Cancer Research obtains United States...
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Sloan-Kettering Institute for Cancer Research (New York, NY) has patented a pharmaceutical composition which comprises the c-kit ligand in combination with other hematopoietic factors. (US 5935565)
- Fred Hutchinson Cancer Research Center obtains United States patent.
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Fred Hutchinson Cancer Research Center (Seattle, WA) has patented a mammalian homology of Drosophila Disabled protein has been identified and cloned. In particular...
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Fred Hutchinson Cancer Research Center (Seattle, WA) has patented an isolated protein designated p27. The p27 protein has an apparent molecular weight of about...
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- News wire article from: TendersInfo July 14, 2009 700+ words
...Somerville, Mass., announced that researchers at the German Cancer Research Center, or DKFZ, in Heidelberg, Germany, will use the...announcement. The intent is to link the research center with other cancer research facilities and university hospitals across Germany. Also...
- United States: Large National Cancer Research Center Selects ATCi's Simulsat...
- News wire article from: TendersInfo August 26, 2009 700+ words
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- Ludwig Institute obtains United States patent.(Ludwig Institute for Cancer...
- Newspaper article from: BIOTECH Patent News October 1, 2001 700+ words
Ludwig Institute for Cancer Research (New York, NY) has patented sdp3.8 tumor associated nucleic acids, including fragments and biologically functional variants...