AccessMyLibrary provides FREE access to over 30 million articles from top publications available through your library.
Create a link to this page
Copy and paste this link tag into your Web page or blog:
Adjuvants interleukin-12 and cholera toxin enhance immunity to HIV-1.
2003 JUL 9 - (NewsRx.com & NewsRx.net) -- Interleukin-12 and cholera toxin subunit B act as adjuvants to enhance mucosal and systemic immunity to human immunodeficiency virus type 1 glycoproteins.
According to recent research published in the Journal of Virology, "We have investigated the induction of protective mucosal immunity to human immunodeficiency virus type 1 (HIV-1) isolate 89.6 by intranasal (i.n.) immunization of mice with gp120 and gp140 together with interleukin-12 (IL-12) and cholera toxin subunit B (CTB) as adjuvants."
"It was found that both IL-12 and CTB were required to elicit mucosal antibody responses and that i.n. immunization resulted in increased total, immunoglobulin G1 (IgG1), and IgG2a anti-HIV-1 antibody levels in serum; increased total, IgG1, IgG2a, and IgA antibody expression in broncho-alveolar lavage fluids; and increased IgA antibody levels in vaginal washes," reported Diana I. Albu and collaborators at Albany Medical College and the Uniformed Services University of the Health Sciences in the United States. "Levels of anti-HIV-1 antibodies in both sera and secretions were higher in groups immunized with gp140 than in those immunized with gp120. However, only gp120-specific mucosal antibodies demonstrated neutralizing activity ...
- Cholera toxin protects against Clostridium difficile toxin A.
- Newspaper article from: Biotech Week January 14, 2004 700+ words
...NewsRx.com & NewsRx.net) -- Cholera toxin protects against action by Clostridium...intestinal fluid secretion induced by the cholera toxin (CT) and Clostridium difficile toxin...antisecretory factor induced via action of cholera toxin on the enteric nervous and immune system...
- Peptide extensions simply, effectively produce detoxified CT...
- Newspaper article from: Vaccine Weekly December 4, 2002 700+ words
...simple procedure to detoxify cholera toxin that maintains immunoadjuvanticity...terminus of the A-subunit of cholera toxin (CTA) to explore whether...could help generate detoxified cholera toxin (CT) derivatives. Proteins...
- Cholera toxin translocates to induce toxicity.
- Newspaper article from: Drug Week February 27, 2004 700+ words
...com & NewsRx.net) -- The cholera toxin translocates to induce toxicity. According...research from the United States, "Cholera toxin (CT) and related AB[subscript...Sciences (The intracellular voyage of cholera toxin: going retro. Trends Biochem Sci...
- Cholera toxin B subunit may not be helpful as adjuvant in pertussis vaccine.
- Newspaper article from: Vaccine Weekly April 9, 2003 700+ words
...NewsRx.com & NewsRx.net) -- Cholera toxin B subunit may not be helpful as an...microgram) with and without recombinant cholera toxin B subunit (rCTB; 10 microgram) as...co-administration with recombinant cholera toxin B subunit as an adjuvant. Vaccine...
- Cholera toxin fights autoimmune disease.
- Magazine article from: Science News Raloff, Janet April 22, 1995 700+ words
...begun harnessing a fragment of the cholera toxin in a novel approach to thwarting autoimmune...recognized as foreign by attaching it to a cholera toxin fragment. When fed to animals, a...Of the two primary components of cholera toxin, only the A chain is actually poisonous...
- Effects of cholera toxin on immunity and its application demonstrated.
- Newspaper article from: Biotech Week July 14, 2004 700+ words
...amp; NewsRx.net) -- Effects of cholera toxin on innate and adaptive immunity and...to recent research from Ireland, "Cholera toxin (CT) is a potent vaccine adjuvant...Journal of Leukocyte Biology (Effects of cholera toxin on innate and adaptive immunity and...
- Modification of cholera toxin B subunit enhances expression in plants.
- Newspaper article from: Drug Week May 7, 2004 700+ words
...net) -- Modification of the cholera toxin B subunit coding sequence enhanced...expression in plants. "The cholera toxin B subunit (CTB) contains five...Breeding (Modification of the cholera toxin B subunit coding sequence to...
- Group B streptococcal protein rib and cholera toxin protect against infection.
- Newspaper article from: Health & Medicine Week April 19, 2004 700+ words
...group B streptococcal protein rib and cholera toxin B subunit confers protection against...administered with the recombinant cholera toxin B subunit, induces systemic immunoglobulin...group B streptococcal protein rib and cholera toxin B subunit confers protection against...
Source: HighBeam Research, Adjuvants interleukin-12 and cholera toxin enhance immunity to HIV-1.