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The FANC-BRCA pathway is disrupted in a subset of ovarian tumor lines.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- The FANC-BRCA pathway is disrupted in a subset of ovarian tumor lines.
"Ovarian tumor cells are often genomically unstable and hypersensitive to cisplatin. To understand the molecular basis for this phenotype, we examined the integrity of the Fanconi anemia-BRCA (FANC-BRCA) pathway in those cells," researchers in England report.
"This pathway regulates cisplatin sensitivity and is governed by the coordinate activity of six genes associated with Fanconi anemia (FANCA, FANCC, FANCD2, FANCE, FANCF and FANCG) as well as BRCA1 and BRCA2 (FANCD1). Here we show that," wrote T. Taniguchi and colleagues, Guys Kings & St. Thomas School of Medicine, Dana Farber Cancer Institute.
"Mono-ubiquitination of FANCD2, a measure of the function of this pathway, and cisplatin resistance were restored by functional complementation with FANCF, a gene that is upstream in this pathway," the researchers stated.
The researchers concluded: "FANCF inactivation in ...
- Benign ovarian tumor.(Causes and Treatment)(Disease/Disorder overview)
- Clinical Reference Systems January 1, 2006 700+ words
What is a benign ovarian tumor? A benign ovarian tumor is a noncancerous growth on or inside an ovary. It...and body hair * weight gain. How is it diagnosed? An ovarian tumor may be discovered when you have a pelvic exam. Tests...
- Ciphergen Engages PrecisionMed, Inc. as Clinical Trial CRO for Ovarian Tumor...
- Press release article from: PR Newswire December 15, 2006 700+ words
...its upcoming clinical trials for its ovarian tumor triage test, including the Ovarian...The selection of a CRO to support our ovarian tumor triage test clinical trial program...Ciphergen on their clinical program for the ovarian tumor triage test," said John Flax, M...
- Vermillion Announces Positive Results From Clinical Trial of Ovarian Tumor...
- Press release article from: PR Newswire March 20, 2008 700+ words
...from a clinical trial evaluating its Ovarian Tumor Triage Test. The study met its primary...Administration (FDA) for clearance. The Ovarian Tumor Triage Test provides information that...chance of being cured. Vermillion's ovarian tumor triage test utilizes a panel of biomarkers...
- Ciphergen Chooses Mosaic to Develop Broad Reimbursement Strategy for Ovarian...
- Press release article from: PR Newswire December 21, 2006 700+ words
...strategies and programs for its ovarian tumor triage test. "The establishment of optimal reimbursement for our ovarian tumor diagnostic program is one crucial...focused on commercializing the ovarian tumor triage test. Quest also has...
- Researchers use nanoparticle-delivered genes to slow ovarian tumor growth
- News wire article from: Xinhua News Agency July 30, 2009 700+ words
Researchers use nanoparticle-delivered genes to slow ovarian tumor growth CHICAGO, July 30 (Xinhua) -- Tiny particles carrying a killer gene can effectively suppress ovarian tumor growth in mice, said U.S. researchers. The findings...
- Ovarian Tumor Index May Prevent Unnecessary Procedures.(Brief Article)
- Magazine article from: AORN Journal March 1, 2000 700+ words
A new ovarian tumor index to help physicians accurately diagnose ovarian tumors as cancerous or benign has been developed by researchers at the University...
- Dendritic cell stimulation restores ovarian-tumor-specific cytotoxicity.
- Newspaper article from: Cancer Weekly April 27, 2004 700+ words
...vivo. "Dendritic cells (DC) are the most powerful professional antigen presenting cells known in humans and recently, ovarian tumor antigen pulsed DC have been shown to elicit tumor specific human leukocyte antigens (HLA)-class I-restricted cytotoxicity...
- 'Suicide' Genes Help Slow Ovarian Tumor Growth in Mice; Treatment could be...
- News wire article from: Consumer Health News (English) July 30, 2009 700+ words
THURSDAY, July 30 (HealthDay News) -- Treatment with "suicide" genes slowed ovarian tumor growth in mice and may one day offer a way to treat late-stage ovarian cancer in women, U.S. scientists say. Currently...
Source: HighBeam Research, The FANC-BRCA pathway is disrupted in a subset of ovarian tumor lines.