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Phenoxodiol induces apoptosis in chemoresistant ovarian cancer cells.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Phenoxodiol induces apoptosis in chemoresistant ovarian cancer cells. According to published research from the United States, "Interference with the innate apoptotic activity is a hallmark of neoplastic transformation and tumor formation.
"In this study we characterize the cytotoxic effect of phenoxodiol, a synthetic anticancer drug analog of genestein, and demonstrate the mechanism of action by which phenoxodiol affects the components of the Fas apoptotic pathway on ovarian cancer cells," wrote M. Kamsteeg and colleagues, Yale University School of Medicine.
"Primary ovarian cancer cells, isolated from ascitic fluids of ovarian cancer patients, resistant to conventional chemotherapy, undergo apoptosis following phenoxodiol treatment," the researchers stated.
"This effect is dependent upon the activation of the caspase system, inhibiting XIAP, an inhibitor of apoptosis, and disrupting FLICE inhibitory protein (FLIP) expression through the Akt signal transduction pathway. We suggest that phenoxodiol is an efficient inducer of cell death in ...
- Shock waves could deliver ribosome-inactivating cytotoxin to cancer...
- Newspaper article from: Cancer Weekly February 18, 2003 700+ words
...tube to permeabilize cancer cells and potentiate the...colorectal cancer HT29 and ovarian cancer OVCAR-5 cells, and...delivery of toxins into cancer cells after intratumoral...protein toxin into cancer cells with shock waves...
- Yale Researchers Find Phenoxodiol Overwhelmingly Effective for Treating...
- Press release article from: PR Newswire May 1, 2003 700+ words
...cell death in 100 percent of ovarian cancer cells, including those cells resistant...induces cell death in primary ovarian cancer cells by inducing apoptosis, and...restores the sensitivity of ovarian cancer cells to "Fas-mediated" apoptosis...
- Experimental Anti-cancer Agent Phenoxodiol Induces Death of Chemo-resistant...
- Press release article from: PR Newswire April 4, 2003 700+ words
...causes chemo-resistant ovarian cancer cells to die are published in the...signaling pathways that regulate ovarian cancer cells, indicating that phenoxodiol...effective agent in causing ovarian cancer cells to undergo cell death...
- Press Release: Yale researchers reveal phenoxodiol's unique ability to kill...
- News wire article from: Asia Africa Intelligence Wire August 27, 2002 700+ words
...uniquely strong effect against ovarian cancer cells. The research team at Yale...effective drug that kills all ovarian cancer cells and does so by a unique mechanism that causes ovarian cancer cells to self-destruct. One...
- Drug compound leads to death of ovarian cancer cells resistant to chemotherapy.
- Press release article from: M2 Presswire April 16, 2008 700+ words
...compound leads to death of ovarian cancer cells resistant to chemotherapy...128 can induce the death of ovarian cancer cells by halting the activation...otherwise chemoresistant ovarian cancer cells, opens new possibilities...
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- Magazine article from: Alternative Medicine Review Chen, X Anderson, JJ October 1, 2002 700+ words
...inhibit the proliferation of ovarian cancer cells in vitro by regulating cytokine...factor-beta 1 production in ovarian cancer cells incubated with genistein...of these two cytokines by ovarian cancer cells. In summary, genistein...
- Marshall Edwards Inc. Begins Trial of Phenoxodiol at Yale University School of...
- Press release article from: PR Newswire December 10, 2002 700+ words
...able to induce cell death in ovarian cancer cells that proved to be resistant...apoptotic proteins in human cancer cells in a highly selective manner...highly effective at killing ovarian cancer cells that are resistant to the killing...
- Resveratrol induces cell death in ovarian cancer cells.
- Newspaper article from: Biotech Week March 24, 2004 700+ words
...present study, the response of ovarian cancer cells to resveratrol is explored...resveratrol induces cell death in ovarian cancer cells through a mechanism distinct...induced autophagocytosis in ovarian cancer cells. Cancer Res, 2004;64...
- Proteins produced by ovarian cancer cells could enable earlier diagnoses.
- Newspaper article from: Medical Letter on the CDC & FDA April 25, 2004 700+ words
...set of proteins produced by ovarian cancer cells serves as a signature for malignancy...subset of proteins produced by ovarian cancer cells that differ in quantity and...proteins mark the presence of ovarian cancer and advance the quest to provide...
- Cyclin E deregulation alters biologic properties of ovarian cancer cells.
- Newspaper article from: OBGYN & Reproduction Week June 7, 2004 700+ words
...alters biologic properties of ovarian cancer cells, resulting in poor prognosis...explored what happens in ovarian cancer cells as a result of low molecular...the biologic properties of ovarian cancer cells. Oncogene, 2004;23...
Source: HighBeam Research, Phenoxodiol induces apoptosis in chemoresistant ovarian cancer cells.