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Gonadotropin treatment of PBMC restores cytokine production to normal.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Idiopathic hypogonadotropic hypogonadism creates abnormal cytokine profiles, and gonadotropin treatment of PBMC returns the effect to normal.
"In the present study, we aimed to investigate the effects of testosterone deficiency and gonadotropin therapy on the in vitro production of TNF-alpha and IL-1beta by peripheral blood mononuclear cells (PBMCs) from patients with idiopathic hypogonadotropic hypogonadism (IHH) in order to elucidate the modulatory role of androgen in cytokine production.
"Fifteen male patients with untreated IHH and 15 age matched, healthy male subjects were enrolled in the study. Serum follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone (FT), sex hormone binding globulin (SHBG), prolactin, IL-2, and IL-4 levels were also measured," scientists writing in the journal Clinical and Experimental Immunology report.
"In unstimulated cultures, IL-1beta and TNF-alpha secretion were not significantly different between patient and control groups. However, after stimulation with lipopolysaccharide (LPS), secretion of IL-1beta and TNF-alpha was significantly higher in cultures from untreated patients with IHH than in control subjects.
"Mean FSH, LH and FT levels were significantly lower, whereas SHBG, IL-2 and IL-4 levels were significantly higher in patients with IHH compared than in controls. In patients with IHH, FT negatively affected the serum levels of IL-4 and in vitro ...
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Source: HighBeam Research, Gonadotropin treatment of PBMC restores cytokine production to normal.