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HEC carcinogenesis results in resistance to 5-fluorouracil-induced apoptosis.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- HEC carcinogenesis results in resistance to 5-fluorouracil-induced apoptosis.
According to recent research published in the European Journal of Pharmacology, "Apoptosis has received widespread attention for its essential roles in biology, medicine and cancer.
"We previously found that normal, human papillomavirus (HPV) 16-immortalized and their transformed endocervical cells were increasingly resistant to apoptosis induced by a cancer therapeutic drug," wrote B. Mo and colleagues, Memorial University of Newfoundland, Faculty of Medicine.
"Here, analogously, another common anticancer drug, 5-fluorouracil, in an ectocervical cell carcinogenesis model induced apoptosis in primary human ectocervical cells (HEC), whereas HPV18-immortalized HEC (HEC-18) and transformed HEC-18 (HEC-18T) were more resistant," the researchers wrote.
"Growth in serum/low density lipoprotein (LDL)-containing medium reversed resistance to 5-fluorouracil-induced apoptosis, particularly in HEC-18T. Cell viability results confirmed these findings. Using Western blots to compare protein levels with those of HEC not treated with 5-fluorouracil, the fold changes in HEC-18 and HEC-18T in LDL-free medium were 1.6-6.1-fold lower for pro-apoptotic p53, Bak and Bax," the researchers stated.
"Four anti-apoptotic proteins were altered - 2.1 to + 14.6-fold for Bcl-2 and BAG-1 isoform p33 and ...
- HEC carcinogenesis results in resistance to 5-fluorouracil-induced apoptosis.
- Newspaper article from: Cancer Weekly July 1, 2003 700+ words
...net) -- HEC carcinogenesis...fluorouracil-induced apoptosis. According...carcinogenesis model induced apoptosis in primary...ectocervical cells (HEC), whereas...fluorouracil-induced apoptosis, particularly in HEC-18T. Cell...
- Cisplatin-induced apoptosis associated with mitochondrial dysregulation.
- Newspaper article from: Obesity, Fitness & Wellness Week June 12, 2004 700+ words
...NewsRx.net) -- Cisplatin-induced apoptosis is associated with mitochondrial...elucidate the mechanisms of CP-induced apoptosis in Hep3B cells, which are Fas...by CP treatment, however, CP-induced apoptosis was not completely blocked by pretreating...
- RIP kinase involved in arsenic-induced apoptosis in multiple myeloma.
- Newspaper article from: Cancer Weekly October 26, 2004 700+ words
...RIP kinase is involved in arsenic-induced apoptosis in multiple myeloma cells. According...compound AT. Both agents potently induced apoptosis in myeloma cells. Exposure to 1...protein in FasL/TNF-alpha/TRAIL induced apoptosis and a major anti-apoptotic adaptor...
- CHOP-induced apoptosis mediated by Bax translocation from mitochondrial cytosol.
- Newspaper article from: Biotech Week June 16, 2004 700+ words
...amp; NewsRx.net) -- CHOP-induced apoptosis is mediated by Bax translocation...not effective in preventing CHOP-induced apoptosis. A mutant dj2 lacking the C-terminal...cells expressing hsp70/dj2. CHOP-induced apoptosis was prevented by Bax knock-down...
- 15-Lipoxygenase-1 mediates cyclooxygenase-2 inhibitor-induced apoptosis.
- Newspaper article from: Cancer Gene Therapy Week April 28, 2003 700+ words
...cyclooxygenase-2 inhibitor-induced apoptosis. According to a study...inhibitor SC-236 similarly induced apoptosis in gastric cancer cells...tested whether SC-236 induced apoptosis through up-regulation...
- MYC loss inactivates the signals required for doxorubicin-induced apoptosis.
- Newspaper article from: Biotech Week July 14, 2004 700+ words
...signals required for doxorubicin-induced apoptosis. "c-Myc plays an essential role...physiological levels of c-Myc in drug-induced apoptosis," scientists in Italy report...involved in executing doxorubicin-induced apoptosis and show caspase-3 activation by...
- Raf/MEK/ERK pathway block sensitizes AML cells to lovastatin-induced apoptosis.
- Newspaper article from: Science Letter December 21, 2004 700+ words
...myelogenous leukemia cells to lovastatin-induced apoptosis. "The statin family of drugs are...play a role in regulating statin-induced apoptosis. Cells derived from acute myelogenous...are not altered during lovastatin-induced apoptosis. By contrast, exposure of primary...
- Potentiation of UVB-induced apoptosis by novel phytosphingosine derivative...
- Newspaper article from: Cancer Weekly August 10, 2004 700+ words
...examines the potentiation of UVB-induced apoptosis by a novel phytosphingosine derivative...tetraacetyl phytosphingosine (TAPS) induced apoptosis in HaCaT cells. This study examined...synergistically increases the level of UVB-induced apoptosis via caspase activation by regulating...