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Patients with chronic hepatitis C and mixed cryoglobulinemia undergo apheresis.
2003 JUL 3 - (NewsRx.com & NewsRx.net) -- Patients with chronic hepatitis C and mixed cryoglobulinemia have undergone immunosorbent apheresis.
"In this short-term open label clinical pilot study, conducted at one center, the immune complex dextran sulphate adsorber (Selesorb(C)) was used to treat four female patients aged 59-69 with HCV-related cryoglobulinaemia, vasculitis and/or neuropathy. The primary trial objective was to assess the clinical efficacy of the immunoadsorber. The secondary objective of the trial was to determine the safety of the adsorber and to investigate the adsorption capacity, measured as the adsorption of cryoglobulin-related immune complexes and the resulting influence on plasma components of the immune system," investigators in Italy reported.
"The patients have been submitted to treatment with the immunoadsorber, at approximately 1-3 days intervals, completing six sessions. The follow-up was one month. In the patients treated with Selesorb(C), we observed a statistically significant decrease in plasma of all classes of immunoglobulins (IgA: 5-28%; IgG: 14-44%; IgM: 8-38%)," reported C. Stefanutti and colleagues, University Roma La Sapienza, Department of Clinical and Applied Medical Therapy.
"In two patients with peripheral neuropathy secondary to cryoglobulinemia, the symptomatology was ...
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